In silico identification of natural product inhibitors for γ‐secretase activating protein, a therapeutic target for Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28316
Abstract: Alzheimer's disease (AD) is clinically characterized by the aggregation of neurotoxic amyloid‐β (Aβ) peptides in the brain. γ‐Secretase catalyzes the reaction of Aβ formation. Inhibition of γ‐secretase activating protein (GSAP) reduces Aβ production without disrupting… read more here.
Keywords: secretase activating; gsap; alzheimer disease; activating protein ... See more keywords
To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01117
Abstract: γ-Secretase activating protein (GSAP) is known to play an important role in the β-amyloid pathway. It acts as a modulator and accentuates the truncation of the amyloid precursor protein C-99 fragment through the γ-secretase complex.… read more here.
Keywords: gsap; isoform; app c99; secretase activating ... See more keywords