Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
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DOI: 10.1016/j.ejmech.2016.09.078
Abstract: The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy. A series of phthalimide and saccharin derivatives linked by different alicyclic fragments (piperazine, hexahydropyrimidine, 3-aminopyrrolidine or 3-aminopiperidine)… read more here.
Keywords: secretase amyloid; saccharin derivatives; phthalimide saccharin; beta ... See more keywords