γ‐Secretase Inhibition Induces Muscle Hypertrophy in a Notch‐Independent Mechanism
Sign Up to like & getrecommendations! Published in 2018 at "PROTEOMICS"
DOI: 10.1002/pmic.201700423
Abstract: A wide variety of cellular processes and signaling events are regulated by the proteolytic enzyme γ‐secretase. Notch‐1 is one of the substrates of γ‐secretase and its role in the regulation of muscle differentiation has been… read more here.
Keywords: secretase; induces muscle; muscle hypertrophy; secretase inhibition ... See more keywords
β-Secretase inhibition by C-methylisoflavones from Abronia nana
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1431637
Abstract: Abstract The methanol extract of Abronia nana suspension cultures were subjected to column chromatography to identify potential inhibitors of β-secretase, which is a major factor in Alzheimer’s disease development. Two new C-methylisoflavones boeravinone T (1)… read more here.
Keywords: methylisoflavones abronia; inhibition methylisoflavones; secretase inhibition; abronia nana ... See more keywords
Selective γ-Secretase Inhibition Is a Potential Target for Leukemias.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-085
Abstract: Targeting γ-secretase subunit PSEN1 blocks mutant NOTCH signaling in T-ALL without severe NOTCH toxicity. read more here.
Keywords: potential target; selective secretase; inhibition potential; target leukemias ... See more keywords