In Vitro Evaluation of Clinical Candidates of γ-Secretase Inhibitors: Effects on Notch Inhibition and Promoting Beige Adipogenesis and Mitochondrial Biogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical research"
DOI: 10.1007/s11095-020-02916-7
Abstract: PURPOSE Inhibition of Notch signaling has been recently demonstrated to promote beige adipocyte biogenesis. However, most γ-secretase inhibitors (GSIs) used to achieve pharmacological inhibition of Notch signaling are at the basic research or preclinical stage,… read more here.
Keywords: secretase inhibitors; inhibition; clinical candidates; notch inhibition ... See more keywords
Gamma secretase inhibitors: a patent review (2013 - 2015)
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DOI: 10.1080/13543776.2017.1313231
Abstract: ABSTRACT Introduction: Gamma secretase (GS) is an intricate and multi-subunits complex, and it can cut various transmembrane proteins. Now it is a therapeutic target for a number of diseases. However, due to some side effects,… read more here.
Keywords: 2013 2015; secretase inhibitors; gamma secretase; review ... See more keywords
Role of γ-Secretase Inhibitors for the Treatment of Diverse Disease Conditions through Inhibition of Notch Signaling Pathway.
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DOI: 10.2174/1389450122666210515161312
Abstract: γ-Secretase is an intramembrane protease sub-assembly which that sunders transmembrane proteins. They are involved in intramembrane proteolysis and also contribute to the regeneration of transmembrane protein. The amyloid precursor protein (APP) is a typical γ-secretase… read more here.
Keywords: protein; secretase inhibitors; disease; signaling pathway ... See more keywords
Gamma Secretase Inhibitors as Potential Therapeutic Targets for Notch Signaling in Uterine Leiomyosarcoma
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DOI: 10.3390/ijms23115980
Abstract: Uterine leiomyosarcoma (uLMS) is a rare and aggressive cancer with few effective therapeutics. The Notch signaling pathway is evolutionarily conserved with oncogenic properties, but it has not been well studied in uLMS. The purpose of… read more here.
Keywords: notch signaling; secretase inhibitors; uterine leiomyosarcoma; expression ... See more keywords
Unlocking the Secrets of Cancer Stem Cells with γ-Secretase Inhibitors: A Novel Anticancer Strategy
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DOI: 10.3390/molecules26040972
Abstract: The dysregulation of Notch signaling is associated with a wide variety of different human cancers. Notch signaling activation mostly relies on the activity of the γ-secretase enzyme that cleaves the Notch receptors and releases the… read more here.
Keywords: cancer stem; gsis; secretase inhibitors; cancer ... See more keywords