Inhibition of γ-Secretase Leads to an Increase in Presenilin-1
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DOI: 10.1007/s12035-017-0705-1
Abstract: Abstractγ-Secretase inhibitors (GSIs) are potential therapeutic agents for Alzheimer’s disease (AD); however, trials have proven disappointing. We addressed the possibility that γ-secretase inhibition can provoke a rebound effect, elevating the levels of the catalytic γ-secretase… read more here.
Keywords: ps1; secretase leads; inhibition; increase ... See more keywords