Extracellular-Signal-Regulated Kinase Inhibition Switches APP Processing from β- to α-Secretase under Oxidative Stress: Modulation of ADAM10 by SIRT1/NF-κB Signaling.
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DOI: 10.1021/acschemneuro.1c00582
Abstract: The sequential cleavage of full-length amyloid precursor protein (APP) by secretases has been at the center of efforts for understanding the onset of Alzheimer's disease (AD). A decrease in α-secretase activity was observed during the… read more here.
Keywords: adam10; secretase oxidative; extracellular signal; stress ... See more keywords