Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.07.008
Abstract: Objective Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondrial… read more here.
Keywords: white adipocytes; adipocyte mitochondrial; human adipocyte; metabolism ... See more keywords
Mesenchymal stem cell‐secreted factors delayed spermatogenesis injuries induced by busulfan involving intercellular adhesion molecule regulation
Sign Up to like & getrecommendations! Published in 2019 at "Andrologia"
DOI: 10.1111/and.13285
Abstract: The present study was designed to investigate the therapeutic effect of bone marrow MSC‐derived factors on gonadotropic toxicity induced by busulfan in vivo. The conditioned media (CM) was obtained from MSCs in serum‐free incubation for… read more here.
Keywords: busulfan; intercellular adhesion; induced busulfan; secreted factors ... See more keywords
Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.17352
Abstract: Linear morphoea (LM) is a rare connective tissue disorder characterized by a line of thickened skin and subcutaneous tissue and can also affect the underlying muscle and bone. Little is known about the disease aetiology,… read more here.
Keywords: differential expression; linear morphoea; expression secreted; factors sostdc1 ... See more keywords
Secreted factors from cultured dental pulp stem cells promoted neurite outgrowth of dorsal root ganglion neurons and ameliorated neural functions in streptozotocin‐induced diabetic mice
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13085
Abstract: Transplantation of stem cells promotes axonal regeneration and angiogenesis in a paracrine manner. In the present study, we examined whether the secreted factors in conditioned medium of stem cells from human exfoliated deciduous teeth (SHED‐CM)… read more here.
Keywords: cultured dental; secreted factors; factors cultured; mice ... See more keywords
Secreted factors from equine mesenchymal stromal cells diminish the effects of TGF‐β1 on equine dermal fibroblasts and alter the phenotype of dermal fibroblasts isolated from cutaneous fibroproliferative wounds
Sign Up to like & getrecommendations! Published in 2017 at "Wound Repair and Regeneration"
DOI: 10.1111/wrr.12515
Abstract: The prevalence of cutaneous fibroproliferative disorders (CFPDs) is high and almost exclusively occurs in humans (keloids and hypertrophic scars) and horses (exuberant granulation tissue), making the horse a valuable translational model for studies on prevention… read more here.
Keywords: mesenchymal stromal; cutaneous fibroproliferative; alter phenotype; secreted factors ... See more keywords
Abstract B205: Intervenolin suppresses gastric cancer cell growth via stromal secreted factors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-b205
Abstract: Background: Tumor-stromal cell interactions are attractive targets for cancer chemotherapy because fibroblast-like stromal cells modulate cancer cells both positively and negatively through secreted factors as well as proteins of the extracellular matrix. We have focused… read more here.
Keywords: cell; gastric cancer; secreted factors; mkn ... See more keywords
SAT-195 Oocyte-Secreted Factors GDF9 and BMP15 Measured in Serum Correlate with Reproductive Potential in Women
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-195
Abstract: Abstract Bone morphogenetic protein-15 (BMP15) and growth differentiation factor-9 (GDF9) are oocyte-secreted factors critical for folliculogenesis, oocyte developmental competence and fertility. BMP15 and GDF9 are produced only by gametes and despite known associations with reproductive… read more here.
Keywords: bmp15; gdf9; oocyte secreted; bmp15 gdf9 ... See more keywords
The effect of mesenchymal stem cell-secreted factors on airway epithelial repair.
Sign Up to like & getrecommendations! Published in 2019 at "Regenerative medicine"
DOI: 10.2217/rme-2018-0020
Abstract: AIM This study was aimed to investigate the effect of mesenchymal stem cell (MSC)-secreted factors on airway repair. MATERIALS & METHODS An indirect in vitro coculture model of injured airway epithelium explant with MSCs was… read more here.
Keywords: factors airway; secreted factors; stem cell; effect mesenchymal ... See more keywords
The regulatory role of metabolic organ-secreted factors in the nonalcoholic fatty liver disease and cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1119005
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a chronic metabolic disease characterized by an excessive accumulation of fat in the liver, which is becoming a major global health problem, affecting about a quarter of the population.… read more here.
Keywords: nonalcoholic fatty; metabolic organ; fatty liver; disease ... See more keywords
Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00778
Abstract: Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected hosts. They… read more here.
Keywords: metabolism; parasites excreted; secreted factors; excreted secreted ... See more keywords
Proteobacteria and Firmicutes Secreted Factors Exert Distinct Effects on Pseudomonas aeruginosa Infection under Normoxia or Mild Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12050449
Abstract: Microbiota may alter a pathogen’s virulence potential at polymicrobial infection sites. Here, we developed a multi-modal Drosophila assay, amenable to the assessment of human bacterial interactions using fly survival or midgut regeneration as a readout,… read more here.
Keywords: pseudomonas aeruginosa; infection; aeruginosa infection; mild hypoxia ... See more keywords