iNSP‐GCAAP: Identifying nonclassical secreted proteins using global composition of amino acid properties
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202100134
Abstract: Nonclassical secreted proteins (NSPs) refer to a group of proteins released into the extracellular environment under the facilitation of different biological transporting pathways apart from the Sec/Tat system. As experimental determination of NSPs is often… read more here.
Keywords: secreted proteins; global composition; amino acid; insp gcaap ... See more keywords
A Vector Suite for the Overexpression and Purification of Tagged Outer Membrane, Periplasmic, and Secreted Proteins in E. coli.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9167-9_11
Abstract: Outer membrane and secreted proteins in Gram-negative bacteria constitute a high percentage of virulence factors that are critical in disease initiation and progression. Despite their importance, it is often difficult to study these proteins due… read more here.
Keywords: outer membrane; membrane periplasmic; secreted proteins; periplasmic secreted ... See more keywords
The external face of Candida albicans: A proteomic view of the cell surface and the extracellular environment.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2017.12.002
Abstract: The cell surface and secreted proteins are the initial points of contact between Candida albicans and the host. Improvements in protein extraction approaches and mass spectrometers have allowed researchers to obtain a comprehensive knowledge of… read more here.
Keywords: candida albicans; cell wall; cell surface; secreted proteins ... See more keywords
Annotated Protein Database Using Known Cleavage Sites for Rapid Detection of Secreted Proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.1c00806
Abstract: Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis of secreted proteins has contributed to our understanding of human disease and physiology but is limited by its need for accurate protein database annotation. Common assumptions used in… read more here.
Keywords: secreted proteins; database; protein database; analysis ... See more keywords
ASPIRER: a new computational approach for identifying non-classical secreted proteins based on deep learning
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac031
Abstract: Protein secretion has a pivotal role in many biological processes and is particularly important for intercellular communication, from the cytoplasm to the host or external environment. Gram-positive bacteria can secrete proteins through multiple secretion pathways.… read more here.
Keywords: deep learning; aspirer new; classical secreted; secretion ... See more keywords
PeNGaRoo, a combined gradient boosting and ensemble learning framework for predicting non-classical secreted proteins
Sign Up to like & getrecommendations! Published in 2020 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz629
Abstract: MOTIVATION Gram-positive bacteria have developed secretion systems to transport proteins across their cell wall, a process that plays an important role during host infection. These secretion mechanisms have also been harnessed for therapeutic purposes in… read more here.
Keywords: secretion; ensemble model; gradient boosting; non classical ... See more keywords
Identification of Secreted Proteins From Malaria Protozoa With Few Features
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DOI: 10.1109/access.2020.2994206
Abstract: Secreted proteins from malaria protozoa play a critical role in the research and development of antimalarial drugs. Therefore, the precise identification of secreted proteins from malaria protozoa is invaluable. Though biochemical experiments can be used… read more here.
Keywords: malaria protozoa; proteins malaria; secreted proteins; identification secreted ... See more keywords
Genome-Wide Analysis and Characterization of the Riemerella anatipestifer Putative T9SS Secretory Proteins with a Conserved C-Terminal Domain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00073-22
Abstract: Riemerella anatipestifer T9SS plays an important role in bacterial virulence. We have previously reported nine R. anatipestifer T9SS-secreted proteins and clarified the function of the metallophosphoesterase. ABSTRACT Riemerella anatipestifer is a major pathogenic agent of… read more here.
Keywords: secreted proteins; t9ss; riemerella anatipestifer; virulence ... See more keywords
Characterization and Spatial Mapping of the Human Gut Metasecretome
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DOI: 10.1128/msystems.00717-22
Abstract: Bacterially secreted proteins are necessary for the proper functioning of bacterial cells and communities. Secreted proteins provide bacterial cells with the ability to harvest resources from the exterior, import these resources into the cell, and… read more here.
Keywords: secreted proteins; gut; human gut; tract ... See more keywords
Abstract 119: Multi-Omics Investigation of Cardiomyocyte-to-Fibroblast Crosstalk in Human iPSC Models
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DOI: 10.1161/res.125.suppl_1.119
Abstract: Introduction: Cardiac cells communicate with each other in part through secreted proteins known as cardiokines. The total repertoire of proteins secreted by cardiac cells is unknown. We aim to apply human iPSC models and large-scale… read more here.
Keywords: multi omics; ipsc models; secreted proteins; cell ... See more keywords
Wnt-induced secreted proteins-1 play an important role in paraquat-induced pulmonary fibrosis
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DOI: 10.1186/s40360-022-00560-y
Abstract: Background The objective of this article is to observe the expression of Wnt-induced secreted proteins-1 (WISP1) in paraquat (PQ)-induced pulmonary fibrosis (PF) to explore the role of WISP1. Methods Healthy individuals were included in the… read more here.
Keywords: expression; role; secreted proteins; induced secreted ... See more keywords