Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury
Sign Up to like & getrecommendations! Published in 2020 at "Hepatology"
DOI: 10.1002/hep.31484
Abstract: The gastrointestinal peptide, secretin (Sct) is an important homeostatic regulator of pancreatic and liver secretory function. With regard to the liver, discoveries have been made, in the last decades, indicating a key role for the… read more here.
Keywords: liver; secretin receptor; secretin secretin; role secretin ... See more keywords
GUB06‐046, a novel secretin/glucagon‐like peptide 1 co‐agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Peptide Science"
DOI: 10.1002/psc.3048
Abstract: Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that the marked body weight‐lowering effects of bariatric surgery involve stimulated secretion of… read more here.
Keywords: glucagon like; mass; mice; gub06 046 ... See more keywords
Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03099-3
Abstract: Recent studies reveal substantial species and regional differences in enteroendocrine cell (EEC) populations, including differences in patterns of hormone coexpression, which limit extrapolation between animal models and human. In this study, jejunal samples, with no… read more here.
Keywords: cell populations; human jejunum; enteroendocrine cell; cell ... See more keywords
Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.016
Abstract: The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing… read more here.
Keywords: prandial thermogenesis; brown fat; bat; satiation ... See more keywords
A study of the clinical utility of a 20-minute secretin-stimulated endoscopic pancreas function test and performance according to clinical variables.
Sign Up to like & getrecommendations! Published in 2017 at "Gastrointestinal endoscopy"
DOI: 10.1016/j.gie.2017.03.1532
Abstract: BACKGROUND AND AIMS Direct pancreas juice testing of bicarbonate, lipase, or trypsin after stimulation by secretin or cholecystokinin is used to determine exocrine function, a surrogate for diagnosing chronic pancreatitis (CP). Endoscopic pancreas function tests… read more here.
Keywords: pbc; test performance; performance; function ... See more keywords
Comparison of Combined Endoscopic Ultrasonography and Endoscopic Secretin Testing With the Traditional Secretin Pancreatic Function Test in Patients With Suspected Chronic Pancreatitis: A Prospective Crossover Study.
Sign Up to like & getrecommendations! Published in 2017 at "Pancreas"
DOI: 10.1097/mpa.0000000000000829
Abstract: OBJECTIVE We aimed to determine the feasibility and accuracy of a combined endoscopic ultrasonography (EUS) with a shortened pancreatic function testing (sEUS) for structural and functional assessment using a single instrument in patients with suspected… read more here.
Keywords: patients suspected; study; pancreatic function; test ... See more keywords
Secretin Regulates Excitatory GABAergic Neurotransmission to GnRH Neurons via Retrograde NO Signaling Pathway in Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00371
Abstract: In mammals, reproduction is regulated by a wide range of metabolic hormones that maintain the proper energy balance. In addition to regulating feeding and energy expenditure, these metabolic messengers also modulate the functional performance of… read more here.
Keywords: gnrh neurons; signaling pathway; neurons via; receptor ... See more keywords
Involvement of Secretin in the Control of Cell Survival and Synaptic Plasticity in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00387
Abstract: With emerging evidence showing a wide distribution of secretin (SCT) and its receptor (SCTR) in the central nervous system (CNS), the putative neuropeptide role of SCT has become more appreciated since the disruption of SCT/SCTR… read more here.
Keywords: survival synaptic; cell survival; nervous system; central nervous ... See more keywords
Secretin Receptor as a Target in Gastrointestinal Cancer: Expression Analysis and Ligand Development
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030536
Abstract: Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid secretion from pancreas and liver and delays gastric emptying. In disease, secretin receptor (SCTR) was found to occur as a splice variant in gastrinoma… read more here.
Keywords: sctr; secretin receptor; secretin; receptor ... See more keywords