Altered glycosylation in secreting cells of the gastric glands of aquaporin‐4‐deficient mice
Sign Up to like & getrecommendations! Published in 2024 at "Microscopy Research and Technique"
DOI: 10.1002/jemt.24563
Abstract: Aquaporins (AQPs) are important for water transport in the gastrointestinal tract. Changes in their expression and/or localization could cause in disorders and be used as therapeutic targets. Aquaporin‐4 (AQP4) is expressed predominantly on the basolateral… read more here.
Keywords: mice; altered glycosylation; parietal cells; gastric glands ... See more keywords
In Vitro Generation of Human Antibody-Secreting Cells Through the Stimulation of PBMCs with Dengue Virus Particles.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1879-0_16
Abstract: The Dengue pathophysiology has had several aspects determined over the years. However, some points remain elusive, such as the metabolic factors that regulate the massive B cell differentiation into antibody-secreting cells observed in Dengue patients.… read more here.
Keywords: secreting cells; antibody secreting; dengue virus;
Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.01.001
Abstract: Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS) that shares many features with the human disease. This review will focus on the role of IL-17-secreting CD4 and γδ T cells in… read more here.
Keywords: secreting cells; th17 cells; multiple sclerosis; role ... See more keywords
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3964
Abstract: Studies of the dynamics of the antibody-mediated immune response have been hampered by the absence of quantitative, high-throughput systems to analyze individual antibody-secreting cells. Here we describe a simple microfluidic system, DropMap, in which single… read more here.
Keywords: single cell; secreting cells; igg; immune monitoring ... See more keywords
A continuously oxygenated macroencapsulation system enables high-density packing and delivery of insulin-secreting cells
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62271-2
Abstract: The encapsulation of insulin-secreting cells within immuno-protective systems holds significant promise for curative treatment of type 1 diabetes without immunosuppression. A major challenge, however, remains the inadequate oxygen tension within the encapsulation systems, which compromises… read more here.
Keywords: system; insulin secreting; oxygen; secreting cells ... See more keywords
Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells
Sign Up to like & getrecommendations! Published in 2024 at "Nature Biotechnology"
DOI: 10.1038/s41587-024-02346-5
Abstract: Monoclonal antibodies are increasingly used to prevent and treat viral infections and are pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and plasmablasts) are an excellent source of high-affinity antibodies with therapeutic potential.… read more here.
Keywords: antibody; antibody secreting; discovery monoclonal; secreting cells ... See more keywords
Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32705-7
Abstract: The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified… read more here.
Keywords: secreting cells; antibody secreting; secretory; site ... See more keywords
Generation of glucose sensitive insulin-secreting cells from human induced pluripotent stem cells on optimized polyethersulfone (PES) hybrid nanofibrous scaffold.
Sign Up to like & getrecommendations! Published in 2022 at "Artificial organs"
DOI: 10.1111/aor.14431
Abstract: BACKGROUND In the realm of diabetes treatment, various strategies have been tried, including islet transplantation and common drug therapies, but the limitations of these procedures and lack of responsive to the high number of patients… read more here.
Keywords: secreting cells; insulin secreting; group; stem ... See more keywords
PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody‐secreting cells from oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Immunology"
DOI: 10.1111/imm.13827
Abstract: Maintaining intracellular redox balance is essential for the survival, antibody secretion, and mucosal immune homeostasis of immunoglobulin A (IgA) antibody‐secreting cells (ASCs). However, the relationship between mitochondrial metabolic enzymes and the redox balance in ASCs… read more here.
Keywords: intestinal homeostasis; antibody; antibody secreting; secreting cells ... See more keywords
HBV promotes the recruitment of IL‐17 secreting T cells via chemokines CCL22 and CCL17
Sign Up to like & getrecommendations! Published in 2020 at "Liver International"
DOI: 10.1111/liv.14438
Abstract: Little is known about the mechanisms of IL‐17 secreting T cells accumulation in HBV‐transfected livers. Here, we investigated the role of the chemokines CCL17, CCL20 and CCL22 in this process. read more here.
Keywords: recruitment secreting; secreting cells; hbv; hbv promotes ... See more keywords
SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin secreting cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260049
Abstract: Glucose sensing in pancreatic beta-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteomics to search for down-stream effectors of glucose dependent signal transduction in INS-1E insulinoma cells, we… read more here.
Keywords: stress; secreting cells; slc25a46; insulin secreting ... See more keywords