Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12237
Abstract: Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant‐derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin‐mediated… read more here.
Keywords: mediated acid; secretion; gastric cancer; gastrin mediated ... See more keywords
Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13144
Abstract: Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation. Previously, we showed the importance of neutrophils and… read more here.
Keywords: secretion; migration thp; ccl2; complement c5a ... See more keywords
Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201910168
Abstract: Oral insulin therapy that targets the liver and further mimics glucose‐responsive secretion holds promise for correcting defects in glucose metabolism caused by peripheral delivery. This work describes the construction of polymersomes (Pep‐PMS), which are composed… read more here.
Keywords: pep pms; hepatic glucose; secretion; insulin ... See more keywords
Mechanism‐Guided Design of Highly Efficient Protein Secretion and Lipid Conversion for Biomanufacturing and Biorefining
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Science"
DOI: 10.1002/advs.201801980
Abstract: Abstract Bacterial protein secretion represents a significant challenge in biotechnology, which is essential for the cost‐effective production of therapeutics, enzymes, and other functional proteins. Here, it is demonstrated that proteomics‐guided engineering of transcription, translation, secretion,… read more here.
Keywords: secretion; secretion lipid; protein secretion; biomanufacturing biorefining ... See more keywords
Photoactivatable Hsp47: A Tool to Regulate Collagen Secretion and Assembly
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DOI: 10.1002/advs.201801982
Abstract: Abstract Collagen is the most abundant structural protein in mammals and is crucial for the mechanical integrity of tissues. Hsp47, an endoplasmic reticulum resident collagen‐specific chaperone, is involved in collagen biosynthesis and plays a fundamental… read more here.
Keywords: collagen; secretion; hsp47 tool; hsp47 ... See more keywords
Distinct TssA proteins converge in coordinating tail biogenesis of the type VI secretion systems
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DOI: 10.1002/bies.202200219
Abstract: Type VI secretion system (T6SS) is a contractile molecular syringe of gram-negative bacteria used to deliver toxins/effectors to the target prokaryotic or eukaryotic cells for antagonism or pathogenesis. This injection system is composed of at… read more here.
Keywords: secretion; distinct tssa; proteins converge; tssa proteins ... See more keywords
A secretion‐based dual fluorescence assay for high‐throughput screening of alcohol dehydrogenases
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27677
Abstract: Alcohol dehydrogenases (ADHs) play key roles in the production of various chemical precursors that are essential in pharmaceutical and fine chemical industries. To achieve a practical application of ADHs in industrial processes, tailoring enzyme properties… read more here.
Keywords: secretion; fluorescence; dual fluorescence; based dual ... See more keywords
Production cell analysis and compound‐based boosting of small extracellular vesicle secretion using a generic and scalable production platform
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28322
Abstract: Extracellular vesicles (EVs) are a novel format of advanced therapeutical medicinal products (ATMPs). They can act regenerative or immune‐modulatory as cell therapy substitutes or as a platform for designer exosomes. The biotechnological production of therapeutic… read more here.
Keywords: cell; production cell; production; secretion ... See more keywords
Targeting MCT4 to reduce lactic acid secretion and glycolysis for treatment of neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1587
Abstract: Development of neuroendocrine prostate cancer (NEPC) is emerging as a major problem in clinical management of advanced prostate cancer (PCa). As increasingly potent androgen receptor (AR)‐targeting antiandrogens are more widely used, PCa transdifferentiation into AR‐independent… read more here.
Keywords: secretion; glycolysis; prostate cancer; acid ... See more keywords
Optimized Hemolysin Type 1 Secretion System in Escherichia coli by Directed Evolution of the Hly Enhancer Fragment and Including a Terminator Region
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202100702
Abstract: Type 1 secretion systems (T1SS) have a relatively simple architecture compared to other classes of secretion systems and therefore, are attractive to be optimized by protein engineering. Here, we report a KnowVolution campaign for the… read more here.
Keywords: region; hly enhancer; secretion; hemolysin ... See more keywords
FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11373
Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that FCRL3 is closely related to MS, but… read more here.
Keywords: p38 mapk; secretion; fcrl3; shp p38 ... See more keywords