Potential role of adenylyl cyclase 8 signaling complexes in regulating insulin secretion from pancreatic beta cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2020.109635
Abstract: Glucose-stimulated insulin secretion from pancreatic β cells is mediated by Ca2+ influx and amplified by stimulation of GLP-1-receptors through cAMP-based signaling pathways. Interestingly, it has been found that glucose-induced Ca2+ signals can induce concurrent adenylyl… read more here.
Keywords: protein; insulin; adenylyl cyclase; insulin secretion ... See more keywords
Blockade of multiple monoamines receptors reduce insulin secretion from pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52590-y
Abstract: Clinical use of olanzapine frequently causes severe hyperglycemia as an adverse effect. In this study, we elucidated mechanisms by which olanzapine reduced insulin secretion using the hamster pancreatic β-cell line HIT-T15. Reverse transcriptional-PCR analysis revealed… read more here.
Keywords: secretion; insulin secretion; ht2b; pancreatic cells ... See more keywords
Immaturity of insulin secretion by pancreatic islets isolated from one human neonate
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DOI: 10.1111/jdi.12701
Abstract: Human β‐cells are functionally mature by the age of 1 year. The timeline and mechanisms of this maturation are unknown owing to the exceptional availability of testable tissue. Here, we report the first in vitro… read more here.
Keywords: secretion; insulin secretion; immaturity insulin; pancreatic islets ... See more keywords
Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells
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DOI: 10.3390/ijms23074003
Abstract: The pathophysiology of type 2 diabetes involves insulin and glucagon. Protein kinase C (Pkc)-δ, a serine–threonine kinase, is ubiquitously expressed and involved in regulating cell death and proliferation. However, the role of Pkcδ in regulating… read more here.
Keywords: secretion pancreatic; induced glucagon; secretion; glucagon secretion ... See more keywords