Promoting Secretion of Pathological Tau Species Using an Induced Proximity Platform That Engages the Autophagy Pathway.
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DOI: 10.1021/acschemneuro.5c00161
Abstract: Intracellular accumulation of aberrantly phosphorylated aggregated tau protein can contribute to neuronal dysfunction associated with many neurodegenerative diseases. Thus, removing such tau species is an attractive therapeutic hypothesis for these diseases. Targeted protein degradation (TPD)… read more here.
Keywords: promoting secretion; pathological tau; tau; secretion pathological ... See more keywords