A Novel Small-Molecule GRP94 Modulator Increases PCSK9 Secretion and Promotes LDLR Degradation
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DOI: 10.3390/life15081321
Abstract: The endoplasmic reticulum (ER) maintains protein homeostasis through chaperone-mediated folding and ER-associated degradation (ERAD). Disruption of this quality control, particularly involving the ER chaperone GRP94, contributes to diseases such as hypercholesterolemia, cancer, and immune disorders,… read more here.
Keywords: increases pcsk9; degradation; secretion promotes; pcsk9 secretion ... See more keywords