Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.10.011
Abstract: Transkingdom secretion systems that bacteria use to inject proteins directly into the cytosol of mammalian host cells play an essential role in the virulence of many Gram-negative bacterial pathogens. Current efforts are underway to repurpose… read more here.
Keywords: secretion; iii secretion; secretion systems; delivery ... See more keywords
The Evolution of Protein Secretion Systems by Co-option and Tinkering of Cellular Machineries.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.01.005
Abstract: Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of… read more here.
Keywords: systems option; secretion; secretion systems; protein secretion ... See more keywords
Freeze! Secretion systems caught in the act
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Microbiology"
DOI: 10.1038/s41579-018-0145-6
Abstract: This month’s Under the Lens discusses electron cryotomography (ECT) as a powerful tool for investigating host–pathogen interactions.This month’s Under the Lens discusses electron cryotomography (ECT) as a powerful tool for investigating host–pathogen interactions. read more here.
Keywords: secretion systems; systems caught; freeze secretion; microbiology ... See more keywords
Conjugative type IV secretion systems enable bacterial antagonism that operates independently of plasmid transfer
Sign Up to like & getrecommendations! Published in 2024 at "Communications Biology"
DOI: 10.1038/s42003-024-06192-8
Abstract: Bacterial cooperation and antagonism mediated by secretion systems are among the ways in which bacteria interact with one another. Here we report the discovery of an antagonistic property of a type IV secretion system (T4SS)… read more here.
Keywords: type secretion; gram negative; secretion systems; secretion ... See more keywords
Deletion of ESX-3 and ESX-4 secretion systems in Mycobacterium abscessus results in highly impaired pathogenicity
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-07572-4
Abstract: Type VII secretion systems participate in protein export, virulence, conjugation, and metabolic regulation. Five subtypes (ESX-1 to ESX-5) exist, each with specific roles and well-characterized secretion profiles in various mycobacterial species. Mycobacterium abscessus, encodes only… read more here.
Keywords: pathogenicity; secretion systems; esx esx; esx secretion ... See more keywords
A systematic survey of type I secretion systems and their substrate proteins in Salmonella
Sign Up to like & getrecommendations! Published in 2025 at "Virulence"
DOI: 10.1080/21505594.2025.2533414
Abstract: ABSTRACT Type I secretion systems (T1SSs) and the substrates have not been investigated extensively in Salmonella, despite their potential significance. In this research, we screened the comprehensive list of Salmonella T1SSs, observed their evolution and… read more here.
Keywords: type secretion; systematic survey; secretion systems; salmonella ... See more keywords
Presence and absence of type VI secretion systems in bacteria.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001151
Abstract: The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would want to miss such superpowers? Indeed, many studies… read more here.
Keywords: secretion systems; presence absence; secretion; type secretion ... See more keywords
Bacterial protein secretion systems: Game of types.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001193
Abstract: Protein trafficking across the bacterial envelope is a process that contributes to the organisation and integrity of the cell. It is the foundation for establishing contact and exchange between the environment and the cytosol. It… read more here.
Keywords: systems game; bacterial protein; secretion systems; protein secretion ... See more keywords
Sensing for survival: specialised regulatory mechanisms of Type III secretion systems in Gram‐negative pathogens
Sign Up to like & getrecommendations! Published in 2024 at "Biological Reviews"
DOI: 10.1111/brv.13047
Abstract: For centuries, Gram‐negative pathogens have infected the human population and been responsible for numerous diseases in animals and plants. Despite advancements in therapeutics, Gram‐negative pathogens continue to evolve, with some having developed multi‐drug resistant phenotypes.… read more here.
Keywords: gram negative; secretion systems; host; type iii ... See more keywords
Transcriptional regulator Sar regulates the multiple secretion systems in Xanthomonas oryzae
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13272
Abstract: Abstract Xanthomonas oryzae pv. oryzae (Xoo) is a notorious plant pathogen that causes leaf blight of rice cultivars. The pathogenic bacteria possess numerous transcriptional regulators to regulate various biological processes, such as pathogenicity in the… read more here.
Keywords: multiple secretion; xanthomonas oryzae; secretion systems; regulator ... See more keywords
Type I Secretion Systems-One Mechanism for All?
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.psib-0003-2018
Abstract: Type I secretion systems (T1SS) are widespread in Gram-negative bacteria, especially in pathogenic bacteria, and they secrete adhesins, iron-scavenger proteins, lipases, proteases, or pore-forming toxins in the unfolded state in one step across two membranes… read more here.
Keywords: microbiology; type secretion; secretion systems; secretion ... See more keywords