Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2017.10.011
Abstract: Transkingdom secretion systems that bacteria use to inject proteins directly into the cytosol of mammalian host cells play an essential role in the virulence of many Gram-negative bacterial pathogens. Current efforts are underway to repurpose… read more here.
Keywords: secretion; iii secretion; secretion systems; delivery ... See more keywords
The Evolution of Protein Secretion Systems by Co-option and Tinkering of Cellular Machineries.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.01.005
Abstract: Protein secretion is important for many biotic and abiotic interactions. The evolution of protein secretion systems of bacteria, and related nanomachines, occurred by the co-option of machineries for motility, conjugation, injection, or adhesion. Some of… read more here.
Keywords: systems option; secretion; secretion systems; protein secretion ... See more keywords
Freeze! Secretion systems caught in the act
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Microbiology"
DOI: 10.1038/s41579-018-0145-6
Abstract: This month’s Under the Lens discusses electron cryotomography (ECT) as a powerful tool for investigating host–pathogen interactions.This month’s Under the Lens discusses electron cryotomography (ECT) as a powerful tool for investigating host–pathogen interactions. read more here.
Keywords: secretion systems; systems caught; freeze secretion; microbiology ... See more keywords
Presence and absence of type VI secretion systems in bacteria.
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DOI: 10.1099/mic.0.001151
Abstract: The type VI secretion system (T6SS) is a molecular puncturing device that enables Gram-negative bacteria to kill competitors, manipulate host cells and take up nutrients. Who would want to miss such superpowers? Indeed, many studies… read more here.
Keywords: secretion systems; presence absence; secretion; type secretion ... See more keywords
Bacterial protein secretion systems: Game of types.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001193
Abstract: Protein trafficking across the bacterial envelope is a process that contributes to the organisation and integrity of the cell. It is the foundation for establishing contact and exchange between the environment and the cytosol. It… read more here.
Keywords: systems game; bacterial protein; secretion systems; protein secretion ... See more keywords
Transcriptional regulator Sar regulates the multiple secretion systems in Xanthomonas oryzae
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Plant Pathology"
DOI: 10.1111/mpp.13272
Abstract: Abstract Xanthomonas oryzae pv. oryzae (Xoo) is a notorious plant pathogen that causes leaf blight of rice cultivars. The pathogenic bacteria possess numerous transcriptional regulators to regulate various biological processes, such as pathogenicity in the… read more here.
Keywords: multiple secretion; xanthomonas oryzae; secretion systems; regulator ... See more keywords
Type I Secretion Systems-One Mechanism for All?
Sign Up to like & getrecommendations! Published in 2019 at "Microbiology spectrum"
DOI: 10.1128/microbiolspec.psib-0003-2018
Abstract: Type I secretion systems (T1SS) are widespread in Gram-negative bacteria, especially in pathogenic bacteria, and they secrete adhesins, iron-scavenger proteins, lipases, proteases, or pore-forming toxins in the unfolded state in one step across two membranes… read more here.
Keywords: microbiology; type secretion; secretion systems; secretion ... See more keywords
Bacterial secretion systems: Networks of pathogenic regulation and adaptation in mycobacteria and beyond
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010610
Abstract: Bacteria transport proteins to diverse intracellular or extracellular locations to ensure proper function. Proteins are localized intracellularly to the cytoplasm or the periplasm or embedded in membranes. Extracellular proteins are localized to the bacterial surface,… read more here.
Keywords: secretion systems; systems networks; secretion; pathogenic regulation ... See more keywords
Molecular architecture of bacterial type IV secretion systems
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010720
Abstract: Bacterial type IV secretion systems (T4SSs) are a versatile group of nanomachines that can horizontally transfer DNA through conjugation and deliver effector proteins into a wide range of target cells. The components of T4SSs in… read more here.
Keywords: bacterial type; molecular architecture; type secretion; secretion systems ... See more keywords
Distribution of Secretion Systems in the Genus Legionella and Its Correlation with Pathogenicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00388
Abstract: The genus Legionella comprises over 60 species, which are important human pathogens. Secretion systems in Legionella pneumophila have been studied extensively because of the essential role of protein secretion in bacterial infection. However, there are… read more here.
Keywords: secretion; secretion systems; genus legionella; non pneumophila ... See more keywords
Comparative Genomics of Aeromonas hydrophila Secretion Systems and Mutational Analysis of hcp1 and vgrG1 Genes From T6SS
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03216
Abstract: Virulent Aeromonas hydrophila causes severe motile Aeromonas septicemia in warmwater fishes. In recent years, channel catfish farming in the U.S.A. and carp farming in China have been affected by virulent A. hydrophila, and genome comparisons… read more here.
Keywords: virulent hydrophila; secretion; secretion system; system ... See more keywords