Immune modulation through secretory autophagy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30427
Abstract: Autophagy is a central mechanism of cellular homeostasis through the degradation of a wide range of cellular constituents. However, recent evidence suggests that autophagy actively provides information to neighboring cells via a process called secretory… read more here.
Keywords: modulation secretory; secretory; secretory autophagy; homeostasis ... See more keywords
Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2022.2157260
Abstract: ABSTRACT Introduction Age-related macular degeneration (AMD) is an eye disease leading to vision loss with poorly known pathogenesis and limited therapeutic options. Degradative autophagy (DA) is impaired in AMD, but emerging evidence points to secretary… read more here.
Keywords: turn key; secretory autophagy; pathology; targets secretory ... See more keywords
Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2123098
Abstract: ABSTRACT High blood glucose is one of the risk factors for metabolic disease and INS (insulin) is the key regulatory hormone for glucose homeostasis. Hypoinsulinemia accompanied with hyperglycemia was diagnosed in mice with pancreatic β-cells… read more here.
Keywords: secretory autophagy; insulin secretion; insulin;
Secretory autophagy-promoted cargo exocytosis requires active RAB37.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2210446
Abstract: RAB37 GTPase regulates cargo exocytosis by cycling between an inactive GDP-bound form and an active GTP-bound form. We reveal that RAB37 simultaneously regulates autophagy activation and tissue inhibitor of metalloproteinase 1 (TIMP1) secretion in lung… read more here.
Keywords: exocytosis; timp1 secretion; lung; secretory autophagy ... See more keywords
Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time
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DOI: 10.3389/fcimb.2018.00362
Abstract: Autophagy, a highly conserved process, serves to maintain cellular homeostasis in response to an extensive variety of internal and external stimuli. The classic, or canonical, pathway of autophagy involves the coordinated degradation and recycling of… read more here.
Keywords: autophagy evs; evs infections; infections perfect; secretory autophagy ... See more keywords
Enterovirus Transmission by Secretory Autophagy
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DOI: 10.3390/v10030139
Abstract: Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding… read more here.
Keywords: transmission secretory; secretory autophagy; enterovirus transmission; secretory ... See more keywords