A molecular switch orchestrates enzyme specificity and secretory granule morphology
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05978-9
Abstract: Regulated secretion is an essential process where molecules destined for export are directed to membranous secretory granules, where they undergo packaging and maturation. Here, we identify a gene (pgant9) that influences the structure and shape… read more here.
Keywords: secretory; secretory granules; morphology; secretory granule ... See more keywords
Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2107665118
Abstract: Significance The failure of β cells to secrete sufficient amounts of insulin is a key feature of diabetes mellitus. Each β cell secretes only a small amount of insulin upon stimulation in a highly regulated… read more here.
Keywords: insulin; vivo; insulin secretory; model ... See more keywords
Amyloid-like aggregation of provasopressin in diabetes insipidus and secretory granule sorting
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biology"
DOI: 10.1186/s12915-017-0347-9
Abstract: BackgroundAggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corresponds to the formation of… read more here.
Keywords: aggregation; secretory; secretory granule; diabetes insipidus ... See more keywords
Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0191
Abstract: A recent discovery effort identified novel splice variant and secretory granule antigens within the HLA class I peptidome of human islets and documented their recognition by CD8 + T cells from peripheral blood and human… read more here.
Keywords: secretory granule; splice; variant secretory; splice variant ... See more keywords