A molecular switch orchestrates enzyme specificity and secretory granule morphology
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05978-9
Abstract: Regulated secretion is an essential process where molecules destined for export are directed to membranous secretory granules, where they undergo packaging and maturation. Here, we identify a gene (pgant9) that influences the structure and shape… read more here.
Keywords: secretory; secretory granules; morphology; secretory granule ... See more keywords
O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules.
Sign Up to like & getrecommendations! Published in 2023 at "Glycobiology"
DOI: 10.1093/glycob/cwad006
Abstract: Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1's diverse functions are attributed to interactions between the modular domains of THBS1 with an array of… read more here.
Keywords: pofut2; type repeats; thbs1; secretory granules ... See more keywords
Characterization of insulin crystalline form in isolated β-cell secretory granules
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220322
Abstract: Insulin is stored in vivo inside the pancreatic β-cell insulin secretory granules. In vitro studies have led to an assumption that high insulin and Zn2+ concentrations inside the pancreatic β-cell insulin secretory granules should promote… read more here.
Keywords: cell; form; insulin crystalline; secretory granules ... See more keywords
Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.202202-0309oc
Abstract: RATIONALE MUC5AC and MUC5B are the predominant secreted polymeric mucins in mammalian airways. They contribute differently to the pathogenesis of various muco-obstructive and interstitial lung diseases, and their genes are separately regulated, but whether they… read more here.
Keywords: muc5b variably; muc5ac muc5b; secretory granules; separate secretory ... See more keywords
Mucins MUC5AC and MUC5B in the Airways: MUCing around Together
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202208-1459ed
Abstract: Chronic obstructive pulmonary disease (COPD) and chronic asthma clinically manifest with sputum production and cough, which correlate with pathologic features such as mucin hypersecretion and airway lumenal mucus accumulation (1, 2). Increased mucin and mucus… read more here.
Keywords: mucins muc5ac; muc5ac; muc5ac muc5b; mucus ... See more keywords
The role of crinophagy in quality control of the regulated secretory pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.260741
Abstract: In specialized secretory cells that produce and release biologically active substances in a regulated fashion, tight control of both the quantity and quality of secretory material is of paramount importance. During crinophagy, abnormal, excess or… read more here.
Keywords: quality control; secretory material; secretory granules; secretory ... See more keywords
Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00792
Abstract: Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental… read more here.
Keywords: glucagon secretion; glucagon; secretory; glucagon interactome ... See more keywords