Secretory pathway Ca2+‐ATPases promote in vitro microcalcifications in breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22695
Abstract: Calcification of the breast is often an outward manifestation of underlying molecular changes that drive carcinogenesis. Up to 50% of all non‐palpable breast tumors and 90% of ductal carcinoma in situ present with radiographically dense… read more here.
Keywords: pathway ca2; breast; secretory pathway; breast cancer ... See more keywords
Filamentous fungi-like secretory pathway strayed in a yeast system: peculiarities of Yarrowia lipolytica secretory pathway underlying its extraordinary performance
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9450-2
Abstract: Microbial production of secretory proteins constitutes one of the key branches of current industrial biotechnology, earning billion dollar (USD) revenues each year. That industrial branch strongly relies on fluent operation of the secretory machinery within… read more here.
Keywords: system; secretory pathway; secretory machinery; pathway ... See more keywords
PACS-1 and adaptor protein-1 mediate ACTH trafficking to the regulated secretory pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.085
Abstract: The regulated secretory pathway is a specialized form of protein secretion found in endocrine and neuroendocrine cell types. Pro-opiomelanocortin (POMC) is a pro-hormone that utilizes this pathway to be trafficked to dense core secretory granules… read more here.
Keywords: protein; adaptor protein; secretory pathway; pacs ... See more keywords
Engineering the endoplasmic reticulum secretory pathway in Trichoderma reesei for improved cellulase production.
Sign Up to like & getrecommendations! Published in 2021 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2021.109923
Abstract: The filamentous fungus Trichoderma reesei is an extraordinarily efficient cell factory of industrial cellulase for production of biofuels and other bio-based products because of its excellent potential to secrete cellulolytic enzymes. Engineering the protein secretory… read more here.
Keywords: secretory pathway; engineering; production; cellulase production ... See more keywords
Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2022.03.009
Abstract: Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we identify metabolic engineering targets limiting expression of recombinant human proteins through a systems biology analysis… read more here.
Keywords: expression; difficult express; secretory pathway; express proteins ... See more keywords
Profiling cysteine reactivity and oxidation in the endoplasmic reticulum.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b01014
Abstract: The endoplasmic reticulum (ER) is the initial site of biogenesis of secretory pathway proteins, including proteins localized to the ER, Golgi, lysosomes, intracellular vesicles, plasma membrane, and extracellular compartments. Proteins within the secretory pathway contain… read more here.
Keywords: endoplasmic reticulum; oxidation; cysteine; secretory pathway ... See more keywords
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15835
Abstract: Exocytic carriers convey neo-synthesized components from the Golgi apparatus to the cell surface. While the release and anterograde movement of Golgi-derived vesicles require the small GTPase RAB6, its effector ELKS promotes the targeting and docking… read more here.
Keywords: towards lysosome; pathway towards; secretory pathway; routing rab6 ... See more keywords
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08429-1
Abstract: Zinc ions (Zn2+) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood. Here, we show that Zn2+ binds with high affinity to the pH-sensitive chaperone… read more here.
Keywords: secretory pathway; zn2; protein quality; early secretory ... See more keywords
Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-13867-y
Abstract: In mammalian cells, >25% of synthesized proteins are exported through the secretory pathway. The pathway complexity, however, obfuscates its impact on the secretion of different proteins. Unraveling its impact on diverse proteins is particularly important for… read more here.
Keywords: predict metabolic; secretory pathway; genome scale; secretion ... See more keywords
Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81447-6
Abstract: Nε-lysine acetylation in the ER is an essential component of the quality control machinery. ER acetylation is ensured by a membrane transporter, AT-1/SLC33A1, which translocates cytosolic acetyl-CoA into the ER lumen, and two acetyltransferases, ATase1… read more here.
Keywords: coa flux; secretory pathway; quality; acetyl coa ... See more keywords
ATase inhibition rescues age-associated proteotoxicity of the secretory pathway
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03118-0
Abstract: Malfunction of autophagy contributes to the progression of many chronic age-associated diseases. As such, improving normal proteostatic mechanisms is an active target for biomedical research and a key focal area for aging research. Endoplasmic reticulum… read more here.
Keywords: secretory pathway; age; atase inhibitors; age associated ... See more keywords