Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15346
Abstract: Sister chromatid attachment during meiosis II (MII) is maintained by securin-mediated inhibition of separase. In maternal ageing, oocytes show increased inter-sister kinetochore distance and premature sister chromatid separation (PSCS), suggesting aberrant separase activity. Here, we… read more here.
Keywords: sister chromatid; securin; meiosis; sister ... See more keywords
Securin-independent regulation of separase by checkpoint-induced shugoshin–MAD2
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2182-3
Abstract: Separation of eukaryotic sister chromatids during the cell cycle is timed by the spindle assembly checkpoint (SAC) and ultimately triggered when separase cleaves cohesion-mediating cohesin 1 – 3 . Silencing of the SAC during metaphase… read more here.
Keywords: separase; securin; shugoshin mad2; checkpoint ... See more keywords
Patronus is the elusive plant securin, preventing chromosome separation by antagonizing separase
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1906237116
Abstract: Significance Accurate chromosome segregation at mitosis and meiosis is crucial to prevent genome instability, birth defect, and cancer. Accordingly, separase, the protease that triggers chromosome distribution, is tightly regulated by a direct inhibitor, the securin.… read more here.
Keywords: pans1; separase; securin; plant securin ... See more keywords
Correlation of securin and Ki67 in invasive breast carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Histology and histopathology"
DOI: 10.14670/hh-18-071
Abstract: AIMS To identify the role of securin (PTTG) as a prognostic marker in invasive breast carcinoma and its possible relation to ki67 and to evaluate the use of ImmunoRatio® as a tool for calculating ki67… read more here.
Keywords: breast carcinoma; securin; securin ki67; breast ... See more keywords
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16447
Abstract: Ubiquitin specific peptidase 44 (USP44) has been identified as an important component of spindle assemble checkpoint (SAC) to prevent the formation of aneuploidy. However, recent study raised a controversy about the effect of USP44 in… read more here.
Keywords: overexpression; securin; glioma; ubiquitin specific ... See more keywords