α‐Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α‐Synuclein in the Context of Co‐Pathology and Non‐LBD Diagnoses
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DOI: 10.1002/ana.26453
Abstract: The purpose of this study was to determine the sensitivity and specificity of α‐synuclein seed amplification assay (αSyn‐SAA) in antemortem and postmortem cerebrospinal fluid (CSF) of autopsy‐confirmed patients with different distributions of pathological αSyn, co‐pathologies,… read more here.
Keywords: seed amplification; brain; patients different; pathology ... See more keywords
Association between the Amplification Parameters of the α‐Synuclein Seed Amplification Assay and Clinical and Genetic Subtypes of Parkinson's Disease
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DOI: 10.1002/mds.30085
Abstract: α‐Synuclein seed amplification assay on cerebrospinal fluid (CSF‐αSyn‐SAA) has shown high accuracy for Parkinson's disease (PD) diagnosis. The analysis of CSF‐αSyn‐SAA parameters may provide useful insight to dissect the heterogeneity of synucleinopathies. read more here.
Keywords: synuclein seed; seed; seed amplification; amplification assay ... See more keywords
QuICSeedR: an R package for analyzing fluorophore-assisted seed amplification assay data
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DOI: 10.1101/2024.08.27.609919
Abstract: Summary Fluorophore-assisted seed amplification assays (F-SAAs), such as real-time quaking-induced conversion (RT-QuIC) and fluorophore-assisted protein misfolding cyclic amplification (F-PMCA), have become indispensable tools for studying protein misfolding in neurodegenerative diseases. However, analyzing data generated by… read more here.
Keywords: seed; fluorophore assisted; seed amplification; saa ... See more keywords
Dermal Alpha‐Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation
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DOI: 10.1111/ene.70453
Abstract: Skin biopsies and seed amplification assays (SAA) provide a sensitive and potentially quantitative method to detect alpha‐synuclein (a‐syn) aggregation in peripheral nerve fibers in Parkinson's disease (PD). Relating to the previously published hypothesis that PD… read more here.
Keywords: seed; seed amplification; aggregation; amplification assays ... See more keywords
Ultrasensitive detection of aggregated α-synuclein using quiescent seed amplification assay for the diagnosis of Parkinson’s disease
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DOI: 10.1186/s40035-024-00426-9
Abstract: Seed amplification assays (SAA) enable the amplification of pathological misfolded proteins, including α-synuclein (αSyn), in both tissue homogenates and body fluids of Parkinson’s disease (PD) patients. SAA involves repeated cycles of shaking or sonication coupled… read more here.
Keywords: seed; seed amplification; amplification; skin samples ... See more keywords
Enhanced serum-based seed amplification assay for detecting propagative α-synuclein seeds in Parkinson’s disease
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DOI: 10.1186/s40035-025-00488-3
Abstract: text Fibrillar aggregates of α-synuclein (αSyn) play a key role in the pathogenesis of Parkinson’s disease (PD) and other synucleinopathies, making them critical targets for diagnostic approaches. In this context, seed amplification assays (SAAs) have… read more here.
Keywords: disease; seed; seed amplification; blood ... See more keywords
α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200878
Abstract: Parkinson disease (PD) is the second most common neurodegenerative disease, and the most common synucleinopathy, as alpha-synuclein (α-syn), a prion-like protein, plays an important pathophysiologic role in its onset and progression. Although neuropathologic changes begin… read more here.
Keywords: diagnosis; seed amplification; disease; amplification assays ... See more keywords
Transition from triggered super-radiance to seed amplification in N2 + lasing.
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DOI: 10.1364/ol.478967
Abstract: Air lasing induced by laser filamentation opens a new route for research on atmospheric molecular physics and remote sensing. The generation of air lasing is composed of two processes, i.e., building up optical gain of… read more here.
Keywords: super radiance; seed amplification; radiance seed; air ... See more keywords