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Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac539
Abstract: Abstract Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2′–5′-RNA modification can substantially reduce…
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Keywords:
safety;
seed pairing;
sirna conjugates;
galnac sirna ... See more keywords