Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b00291
Abstract: Chemical modifications of 2′-O-methyl (2′-OMe) and locked nucleic acid (LNA) of the nucleotides in the seed region (positions 2–8) of the small interfering RNA (siRNA) guide strand significantly reduced seed-matched (SM) off-target effects. The siRNA… read more here.
Keywords: target effects; seed; target; seed region ... See more keywords
Association between polymorphisms in microRNA seed region and warfarin stable dose
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DOI: 10.1136/postgradmedj-2019-137197
Abstract: Background The optimal dose of anticoagulant warfarin varies among patients to achieve the target international normalised ratio. Although genetic variations related to warfarin pharmacokinetics and vitamin K cycle are important factors associated with warfarin dose… read more here.
Keywords: warfarin; seed; warfarin dose; seed region ... See more keywords
An Alternative Class of Targets for microRNAs Containing CG Dinucleotide
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DOI: 10.3390/biology11030478
Abstract: Simple Summary MicroRNAs are ~23 nt, highly conserved non-coding RNA molecules involved in the regulation of target gene expression. Most of the microRNA-target prediction algorithms rely heavily on seed rules and evolutionary conservation. However, such… read more here.
Keywords: bulge targets; seed region; micrornas containing; seed ... See more keywords