Decrease in Skin Prion-Seeding Activity of Prion-Infected Mice Treated with a Compound Against Human and Animal Prions: a First Possible Biomarker for Prion Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02418-6
Abstract: Previous studies have revealed that the infectious scrapie isoform of prion protein (PrPSc) harbored in the skin tissue of patients or animals with prion diseases can be amplified and detected through the serial protein misfolding… read more here.
Keywords: prion; seeding activity; prion diseases; prion seeding ... See more keywords
Sclerotiorin stabilizes the assembly of non-fibrillar Abeta42 oligomers with low toxicity, seeding activity and beta-sheet content.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.033
Abstract: The self-assembly of the 42-residue amyloid-β peptide, Aβ42, into fibrillar aggregates is associated with neuronal dysfunction and toxicity in Alzheimer's disease (AD) patient brains, suggesting that small molecules acting on this process might interfere with… read more here.
Keywords: sheet content; low toxicity; seeding activity; sheet ... See more keywords
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aam7785
Abstract: Infectious prions can be detected in the skin of patients with sporadic Creutzfeldt-Jakob disease. Prions in unexpected places Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, can be transmitted via neurosurgical instruments or… read more here.
Keywords: prion; skin; disease; seeding activity ... See more keywords
Two simple assays for assessing the seeding activity of proteopathic tau
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1073774
Abstract: The regional distribution of neurofibrillary tangles of hyperphosphorylated tau aggregates is associated with the progression of Alzheimer’s disease (AD). Misfolded proteopathic tau recruits naïve tau and templates its misfolding and aggregation in a prion-like fashion,… read more here.
Keywords: seeding activity; aggregation; proteopathic tau; two simple ... See more keywords
Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer’s Brain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.631833
Abstract: Accumulation of intracellular neurofibrillary tangles (NFTs), which are constituted of abnormally phosphorylated tau, is one of the neuropathological hallmarks of Alzheimer’s disease (AD). The oligomeric aggregates of tau in AD brain (AD O-tau) are believed… read more here.
Keywords: tau; seeding activity; dephosphorylation; dephosphorylation passivates ... See more keywords