Seeding amplification assay: Limitations and insights for enhanced clinical and research applications
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Parkinson's Disease"
DOI: 10.1177/1877718x251325124
Abstract: The accurate diagnosis of synucleinopathies—neurodegenerative diseases marked by misfolded α-synuclein protein aggregates, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy—remains a critical challenge. Conventional clinical criteria, frequently verified only through postmortem… read more here.
Keywords: diagnosis; disease; saa; seeding amplification ... See more keywords
Accurate detection of pathologic α-synuclein in CSF, skin, olfactory mucosa, and urine with a uniform seeding amplification assay
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-025-02034-8
Abstract: Currently, early diagnosis of dementia with Lewy bodies (DLB) is based on clinical criteria, which is challenging due to overlapping symptoms with other neurodegenerative diseases. Seeding amplification assays, detecting minute amounts of disease causing α-synuclein… read more here.
Keywords: detection; olfactory mucosa; csf; amplification assay ... See more keywords