APOE Antibody Inhibits Aβ‐Associated Tau Seeding and Spreading in a Mouse Model
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DOI: 10.1002/ana.26351
Abstract: APOE is the strongest genetic factor for late‐onset Alzheimer's disease (AD). A specific conformation of the ApoE protein is present in amyloid‐β (Aβ) containing plaques. Immunotherapy targeting ApoE in plaques reduces brain Aβ deposits in… read more here.
Keywords: inhibits associated; antibody inhibits; apoe antibody; tau seeding ... See more keywords
The cellular prion protein does not affect tau seeding and spreading of sarkosyl-insoluble fractions from Alzheimer’s disease
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DOI: 10.1038/s41598-024-72232-2
Abstract: The cellular prion protein (PrPC) plays many roles in the developing and adult brain. In addition, PrPC binds to several amyloids in oligomeric and prefibrillar forms and may act as a putative receptor of abnormal… read more here.
Keywords: sarkosyl insoluble; seeding spreading; tau seeding; tau ... See more keywords
Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum
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DOI: 10.3390/ijms23020718
Abstract: Several studies have demonstrated the different characteristics of tau seeding and spreading following intracerebral inoculation in murine models of tau-enriched fractions of brain homogenates from AD and other tauopathies. The present study is centered on… read more here.
Keywords: tau; host tau; seeding spreading; tau seeding ... See more keywords
Endocytic Pathways Unveil the Role of Syndecans in the Seeding and Spreading of Pathological Protein Aggregates: Insights into Neurodegenerative Disorders
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DOI: 10.3390/ijms26094037
Abstract: Alzheimer’s disease and other neurodegenerative disorders are characterized by the accumulation of misfolded proteins, such as amyloid-beta, tau, and α-synuclein, which disrupt neuronal function and contribute to cognitive decline. Heparan sulfate proteoglycans, particularly syndecans, play… read more here.
Keywords: seeding spreading; protein aggregates; endocytic pathways; spreading pathological ... See more keywords