Segmental bone replacement via patient‐specific, three‐dimensional printed bioresorbable graft substitutes and their use as templates for the culture of mesenchymal stem cells under mechanical stimulation at various frequencies
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26780
Abstract: The treatment of large segmental bone defects remains a challenge as infection, delayed union, and nonunion are common postoperative complications. A three‐dimensional printed bioresorbable and physiologically load‐sustaining graft substitute was developed to mimic native bone… read more here.
Keywords: graft; tissue; segmental bone; bone ... See more keywords
Biomimetic periosteum-bone substitute composed of preosteoblast-derived matrix and hydrogel for large segmental bone defect repair.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.06.030
Abstract: Repairing large segmental bone defects above a critical size remains challenging with high risk of delayed union or even non-union. From the perspective of bone development and clinical experience, periosteum plays an indispensable role in… read more here.
Keywords: segmental bone; bone; podm; derived matrix ... See more keywords
All Internal Segmental Bone Transport and Optional Lengthening With a Newly Developed Universal Cylinder-Kombi-Tube Module for Motorized Nails-Description of a Surgical Technique.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of orthopaedic trauma"
DOI: 10.1097/bot.0000000000000986
Abstract: Segmental transport is an effective method of treatment for segmental defects, but the need for external fixation during the transport phase is a disadvantage. To avoid external fixation, we have developed a Cylinder-Kombi-Tube Segmental Transport… read more here.
Keywords: module; transport; cylinder kombi; segmental bone ... See more keywords
Segmental Bone Defects and the History of Bone Transport.
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DOI: 10.1097/bot.0000000000002124
Abstract: SUMMARY This article describes the etiology of segmental bone defects and reviews the options of care, past and present. A brief description of distraction osteogenesis and how the Ilizarov method was used to treat bone… read more here.
Keywords: segmental bone; transport; defects history; bone defects ... See more keywords
Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw1228
Abstract: Use of BMP-2 and lysostaphin-loaded hydrogels simultaneously clears S. aureus infection and repairs bone defects. Staphylococcus aureus is the most common pathogen associated with bacterial infections in orthopedic procedures. Infections often lead to implant failure… read more here.
Keywords: aureus infection; lysostaphin delivering; infection; segmental bone ... See more keywords
Artificial Membrane Induced by Novel Biodegradable Nanofibers in the Masquelet Procedure for Treatment of Segmental Bone Defects
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Nanomaterials"
DOI: 10.1155/2018/8246571
Abstract: The Masquelet induced-membrane technique for the treatment of segmental bone defects includes a two-stage surgical procedure, and polymethylmethacrylate (PMMA) plays a major role in the treatment. However, the PMMA spacer must be surgically removed. Here,… read more here.
Keywords: treatment segmental; segmental bone; bone; bone defects ... See more keywords
Circular external fixation and cemented PMMA spacers for the treatment of complex tibial fractures and infected nonunions with segmental bone loss
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Surgery"
DOI: 10.1177/2309499017716242
Abstract: Purpose: The purpose of this study was to compare the outcome of combined circular external fixation and cemented polymethylmethacrylate (PMMA) spacer application between a cohort of patients with grade 3 open fractures and infected tibial… read more here.
Keywords: circular external; tibial fractures; segmental bone; bone ... See more keywords
Effects of Channels and Micropores in Honeycomb Scaffolds on the Reconstruction of Segmental Bone Defects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.825831
Abstract: The reconstruction of critical-sized segmental bone defects is a key challenge in orthopedics because of its intractability despite technological advancements. To overcome this challenge, scaffolds that promote rapid bone ingrowth and subsequent bone replacement are… read more here.
Keywords: honeycomb scaffolds; bone; channels micropores; segmental bone ... See more keywords
LL-37-Coupled Porous Composite Scaffold for the Treatment of Infected Segmental Bone Defect
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010088
Abstract: Increased multiantibiotic-resistant bacteria means that infected bone defects remain a significant challenge to clinics. Great interest has emerged in the use of non-antibiotic antimicrobials to reduce the rate of multiantibiotic-resistant bacterial infection and facilitate bone… read more here.
Keywords: bone; segmental bone; bone defect; group ... See more keywords