The kinetics in mathematical models on segmentation clock genes in zebrafish
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-017-1138-1
Abstract: Somitogenesis is the process for the development of somites in vertebrate embryos. This process is timely regulated by synchronous oscillatory expression of the segmentation clock genes. Mathematical models expressed by delay equations or ODEs have… read more here.
Keywords: segmentation; segmentation clock; model; mathematical models ... See more keywords
Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental biology"
DOI: 10.1016/j.ydbio.2022.04.004
Abstract: In mammalian development, oscillatory activation of Notch signaling is required for segmentation clock function during somitogenesis. Notch activity oscillations are synchronized between neighboring cells in the presomitic mesoderm (PSM) and have a period that matches… read more here.
Keywords: dll3; activation; notch; activity ... See more keywords
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114083119
Abstract: Significance Although the circadian clock is essential for regulating the temporal order of physiological functions, circadian oscillation is strictly suppressed in the early-to-mid–stage embryos in mammalian developmental process. The biological significance controlling the suppression of… read more here.
Keywords: clock bmal1; segmentation clock; clock; circadian key ... See more keywords
CDK1 and CDK2 regulate NICD1 turnover and the periodicity of the segmentation clock
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201846436
Abstract: All vertebrates share a segmented body axis. Segments form from the rostral end of the presomitic mesoderm (PSM) with a periodicity that is regulated by the segmentation clock. The segmentation clock is a molecular oscillator… read more here.
Keywords: periodicity; clock; segmentation clock; cdk1 cdk2 ... See more keywords