A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve†
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DOI: 10.1093/biolre/ioz089
Abstract: Abstract A major challenge in medical genetics is to characterize variants of unknown significance (VUS). Doing so would help delineate underlying causes of disease and the design of customized treatments. Infertility has presented an especially… read more here.
Keywords: segregating human; mice; human allele; recombination ... See more keywords