Intrinsically Defective Microtubule Dynamics Contribute to Age-Related Chromosome Segregation Errors in Mouse Oocyte Meiosis-I
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.02.025
Abstract: Chromosome segregation errors in mammalian oocytes compromise development and are particularly prevalent in older females, but the aging-related cellular changes that promote segregation errors remain unclear [1, 2]. Aging causes a loss of meiotic chromosome… read more here.
Keywords: microtubule dynamics; chromosome; segregation errors; age related ... See more keywords
Longer metaphase and fewer chromosome segregation errors in modern human than Neanderthal brain development
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.03.30.486431
Abstract: Since the ancestors of modern humans separated from those of Neandertals, around one hundred amino acid substitutions spread to essentially all modern humans. The biological significance of these changes is largely unknown. Here, we examine… read more here.
Keywords: modern human; chromosome segregation; segregation errors; modern humans ... See more keywords
Centrosome Linker–induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-0062
Abstract: Centrosome anomalies contribute to tumorigenesis, but it remains unclear how they are generated in lethal cancer phenotypes. Here, it is demonstrated that human microsatellite instable (MSI) and BRAFV600E-mutant colorectal cancers with a lethal rhabdoid phenotype… read more here.
Keywords: segregation errors; tetraploid segregation; segregation; colorectal cancers ... See more keywords