Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors
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DOI: 10.1002/cmdc.202200137
Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammationârelated pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and… read more here.
Keywords: seh; seh inhibitors; soluble epoxide; epoxide hydrolase ... See more keywords
Soluble Epoxide Hydrolase-Derived Linoleic Acid Oxylipins in Serum Are Associated with Periventricular White Matter Hyperintensities and Vascular Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2018 at "Translational Stroke Research"
DOI: 10.1007/s12975-018-0672-5
Abstract: White matter hyperintensities (WMH) are presumed to indicate subcortical ischemic vascular disease but their underlying pathobiology remains incompletely understood. The soluble epoxide hydrolase (sEH) enzyme converts anti-inflammatory and vasoactive cytochrome p450-derived polyunsaturated fatty acid epoxides… read more here.
Keywords: cognitive impairment; vascular cognitive; seh; white matter ... See more keywords
3 Vragen over Opleidingsboost op de seh
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DOI: 10.1007/s41193-020-0114-0
Abstract: Wie: Gerrit van de Groep is klinisch verpleegkundig opleider op de spoedeisende hulp (seh) van OLVG in Amsterdam. Wat: Samen met het seh-team zorgde hij voor het opleiden van extra sehverpleegkundigen, waardoor er nu ruim… read more here.
Keywords: opleidingsboost seh; van; seh; vragen opleidingsboost ... See more keywords
A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.102107
Abstract: Soluble epoxide hydrolase (sEH), an enzyme that broadly regulates the cardiovascular system, hydrolyses epoxyeicosatrienoic acids (EETs) to their corresponding dihydroxyeicosatrienoic acids (DHETs). We previously showed that endogenous lipid electrophiles adduct within the catalytic domain, inhibiting… read more here.
Keywords: soluble epoxide; epoxide hydrolase; seh; redox ... See more keywords
Evaluating the protective effects of individual or combined ginsenoside compound K and the downregulation of soluble epoxide hydrolase expression against sodium valproate-induced liver cell damage.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115555
Abstract: Sodium valproate (SVP) is one of the most commonly prescribed antiepileptic drugs. However, SVP is known to induce hepatotoxicity, which limits its clinical application for treating various neurological disorders. Previously, we found that ginsenoside compound… read more here.
Keywords: ginsenoside compound; svp induced; seh; expression ... See more keywords
Discovery and Optimization of Indoline-Based Compounds as Dual 5-LOX/sEH Inhibitors: In Vitro and In Vivo Anti-Inflammatory Characterization
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00817
Abstract: The design of multitarget drugs represents a promising strategy in medicinal chemistry and seems particularly suitable for the discovery of anti-inflammatory drugs. Here, we describe the identification of an indoline-based compound inhibiting both 5-lipoxygenase (5-LOX)… read more here.
Keywords: lox; seh; lox seh; indoline based ... See more keywords
Macrophage Inactivation by Small Molecule Wedelolactone via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.2c01424
Abstract: Soluble epoxide hydrolase (sEH) plays a critical role in inflammation by modulating levels of epoxyeicosatrienoic acids (EETs) and other epoxy fatty acids (EpFAs). Here, we investigate the possible role of sEH in lipopolysaccharide (LPS)-mediated macrophage… read more here.
Keywords: seh; acute lung; small molecule; lung injury ... See more keywords
Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition
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DOI: 10.1021/acsomega.2c04039
Abstract: Soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs), which are endowed with beneficial biological activities as they reduce inflammation, regulate endothelial tone, improve mitochondrial function, and decrease oxidative stress. Therefore, inhibition of sEH for maintaining… read more here.
Keywords: seh; inhibition; lipoxygenase activating; soluble epoxide ... See more keywords
Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors
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DOI: 10.1021/acsomega.2c06936
Abstract: Inhibition of soluble epoxide hydrolase (sEH) is indicated as a new therapeutic modality against a variety of inflammatory diseases, including metabolic, renal, and cardiovascular disorders. In our ongoing research on sEH inhibitors, we synthesized novel… read more here.
Keywords: seh; benzoxazolone urea; seh inhibitors; soluble epoxide ... See more keywords
Soluble epoxide hydrolase inhibitors: an overview and patent review from the last decade.
Sign Up to like & getrecommendations! Published in 2022 at "Expert opinion on therapeutic patents"
DOI: 10.1080/13543776.2022.2054329
Abstract: INTRODUCTION Biological effects mediated by the CYP450 arm of arachidonate cascade implicate the enzyme-soluble epoxide hydrolase (sEH) in hydrolyzing anti-inflammatory epoxy fatty acids to pro-inflammatory diols. Hence, inhibiting the sEH offers a therapeutic approach to… read more here.
Keywords: epoxide hydrolase; seh; soluble epoxide; last decade ... See more keywords
The role of cytochrome p450 and soluble epoxide hydrolase enzymes and their associated metabolites in the pathogenesis of diabetic cardiomyopathy.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000707
Abstract: A plethora of studies have demonstrated that cardiomyopathy represents a serious source of morbidity and mortality in patients with diabetes. Yet, the underlying mechanisms of diabetic cardiomyopathy are still poorly understood. Of interest, cytochrome P450… read more here.
Keywords: epoxide hydrolase; cytochrome p450; seh; diabetic cardiomyopathy ... See more keywords