Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors
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DOI: 10.1002/cmdc.202200137
Abstract: Soluble epoxide hydrolase (sEH) is implicated as a potential therapeutic target for inflammation‐related pathologies in the context of cardiovascular, central nervous system and metabolic diseases. In our search for novel sEH inhibitors, we designed and… read more here.
Keywords: seh; seh inhibitors; soluble epoxide; epoxide hydrolase ... See more keywords
Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.
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DOI: 10.1021/acs.jmedchem.0c01507
Abstract: Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and… read more here.
Keywords: soluble epoxide; epoxide hydrolase; hydrolase; seh inhibitors ... See more keywords
Benzoxazolone-5-Urea Derivatives as Human Soluble Epoxide Hydrolase (sEH) Inhibitors
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DOI: 10.1021/acsomega.2c06936
Abstract: Inhibition of soluble epoxide hydrolase (sEH) is indicated as a new therapeutic modality against a variety of inflammatory diseases, including metabolic, renal, and cardiovascular disorders. In our ongoing research on sEH inhibitors, we synthesized novel… read more here.
Keywords: seh; benzoxazolone urea; seh inhibitors; soluble epoxide ... See more keywords
Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen‐glucose deprivation
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DOI: 10.1111/jnc.13933
Abstract: Epoxyeicosatrienoic acids (EETs) are synthesized in astrocytes, and inhibitors of soluble epoxide hydrolase (sEH), which hydrolyzes EETs, reduce infarct volume in ischemic stroke. Astrocytes can release protective neurotrophic factors, such as vascular endothelial growth factor… read more here.
Keywords: soluble epoxide; vegf; vascular endothelial; endothelial growth ... See more keywords