SEIPIN overexpression in the liver may alleviate hepatic steatosis by influencing the intracellular calcium level
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.03.005
Abstract: SEIPIN deficiency leads to a severe lipodystrophic phenotype with loss of fat tissue. Interestingly, SEIPIN knockout in non-adipocytes is reported to promote intracellular triacylglycerol (TG) accumulation. However, the underlying mechanisms remain unclear at present. Here,… read more here.
Keywords: overexpression; intracellular calcium; seipin overexpression; seipin ... See more keywords
Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59982-5
Abstract: Seipin deficiency causes severe congenital generalized lipodystrophy (CGL) and metabolic disease. However, how seipin regulates adipocyte development and function remains incompletely understood. We previously showed that seipin acts as a scaffold protein for AGPAT2, whose… read more here.
Keywords: seipin; gpat3 agpat2; gpat3; adipocyte differentiation ... See more keywords
Seipin—still a mysterious protein?
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1112954
Abstract: Cells store excess energy in the form of lipid droplets (LDs), a specialized sub-compartment of the endoplasmic reticulum (ER) network. The lipodystrophy protein seipin is a key player in LD biogenesis and ER-LD contact site… read more here.
Keywords: still mysterious; mysterious protein; protein seipin; seipin ... See more keywords
Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.782194
Abstract: Exercise, typically beneficial for skeletal health, has not yet been studied in lipodystrophy, a condition characterized by paucity of white adipose tissue, with eventual diabetes, and steatosis. We applied a mouse model of global deficiency… read more here.
Keywords: bone; marrow adiposity; lipodystrophy; seipin ... See more keywords
Role of Seipin in Human Diseases and Experimental Animal Models
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DOI: 10.3390/biom12060840
Abstract: Seipin, a protein encoded by the Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) gene, is famous for its key role in the biogenesis of lipid droplets and type 2 congenital generalised lipodystrophy (CGL2). BSCL2 gene mutations… read more here.
Keywords: animal models; human diseases; seipin; bscl2 gene ... See more keywords
SEIPIN: A Key Factor for Nuclear Lipid Droplet Generation and Lipid Homeostasis
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21218208
Abstract: Lipid homeostasis is essential for normal cell physiology. Generally, lipids are stored in a lipid droplet (LD), a ubiquitous organelle consisting of a neutral lipid core and a single layer of phospholipid membrane. It is… read more here.
Keywords: homeostasis; seipin; generation; lipid droplet ... See more keywords