Seizing Control of KCC2: A New Therapeutic Target for Epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2017.06.008
Abstract: Deficits in GABAergic inhibition result in the abnormal neuronal activation and synchronization that underlies seizures. However, the molecular mechanisms responsible for transforming a normal brain into an epileptic one remain largely unknown. Hyperpolarizing inhibition mediated… read more here.
Keywords: epilepsy; kcc2 new; seizing control; new therapeutic ... See more keywords
Seizing Control of Neuronal Activity: Chemogenetic Applications in Epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221120348
Abstract: The fundamental commonality across pharmacotherapies for the epilepsies is the modulation of neuronal excitability. This poses a clear challenge—patterned neuronal excitation is essential to normal function, thus disrupting this activity leads to side effects. Moreover,… read more here.
Keywords: seizing control; chemogenetic applications; activity; neuronal activity ... See more keywords