Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long‐term
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51620
Abstract: Recently, we showed that resection of at least 27% of the temporal part of piriform cortex (PiC) strongly correlated with seizure freedom 1 year following selective amygdalo‐hippocampectomy (tsSAHE) in patients with mesial temporal lobe epilepsy (mTLE).… read more here.
Keywords: long term; seizure; piriform cortex; temporal lobe ... See more keywords
Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51815
Abstract: Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case… read more here.
Keywords: seizure; network modulation; pulvinar; temporal plus ... See more keywords
Is seizure frequency variance a predictable quantity?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.519
Abstract: There is currently no formal method for predicting the range expected in an individual's seizure counts. Having access to such a prediction would be of benefit for developing more efficient clinical trials, but also for… read more here.
Keywords: neurology; seizure frequency; variance predictable; predictable quantity ... See more keywords
Development and validation of forecasting next reported seizure using e-diaries.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of neurology"
DOI: 10.1002/ana.25812
Abstract: OBJECTIVE There are no validated methods for predicting the timing of seizures. Using machine learning, we sought to forecast 24-hour risk of self-reported seizure from e-diaries. METHODS Data from 5,419 patients of SeizureTracker.com (including seizure… read more here.
Keywords: development validation; brier score; seizure; reported seizure ... See more keywords
Comparing seizure-related death and suicide in younger adults with epilepsy.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of neurology"
DOI: 10.1002/ana.26227
Abstract: Younger adults with epilepsy have an increased mortality. Some deaths are seizure-related, e.g. sudden unexpected death in epilepsy (SUDEP), while others, e.g. suicide, have multiple causes including adverse effects of the treatment on mood. In… read more here.
Keywords: death; related death; adults epilepsy; younger adults ... See more keywords
CRISPR-based KCC2 upregulation attenuates drug-resistant seizure in mouse models of epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26656
Abstract: OBJECTIVE Precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive. METHODS Here, we employed a CRISPRa system delivered by adeno-associated viruses (AAV) to specifically upregulate KCC2 in… read more here.
Keywords: epilepsy; kcc2 upregulation; seizure; drug resistant ... See more keywords
Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11874
Abstract: In previous studies, we found that dynorphin exerts antiepileptic effect by activating the kappa opioid receptor (KOR). However, the role of neuronal autophagy in dynorphin/KOR‐mediated antiepileptic is still unclear. This study aimed to investigate the… read more here.
Keywords: seizure; signaling pathway; mtor signaling; epilepsy ... See more keywords
Deep Learning-based Seizure Detection and Prediction from EEG Signals.
Sign Up to like & getrecommendations! Published in 2022 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3573
Abstract: Electroencephalography (EEG) is a tool used for analyzing and diagnosing epilepsy. The manual analysis of EEG must be conducted by highly trained clinicians or neuro-physiologists; a process that is considered to have comparatively low inter-rater… read more here.
Keywords: eeg; seizure detection; prediction; classification ... See more keywords
Dissociation of spontaneous seizures and brainstem seizure thresholds in mice exposed to eight flurothyl‐induced generalized seizures
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12031
Abstract: C57BL/6J mice exposed to eight flurothyl‐induced generalized clonic seizures exhibit a change in seizure phenotype following a 28‐day incubation period and subsequent flurothyl rechallenge. Mice now develop a complex seizure semiology originating in the forebrain… read more here.
Keywords: eight flurothyl; brainstem seizure; flurothyl induced; exposed eight ... See more keywords
Improving clinical trial efficiency: Is technology the answer?
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12042
Abstract: Adjunctive randomized placebo-controlled trials are the gold standard for determining whether new antiseizure drugs (ASDs) are effective for patients with treatmentresistant epilepsy. In these studies, patients receiving the novel ASD as an add-on are compared… read more here.
Keywords: medicine; trial; seizure; controlled trials ... See more keywords
High‐frequency oscillations detected in ECoG recordings correlate with cavernous malformation and seizure‐free outcome in a child with focal epilepsy: A case report
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsia Open"
DOI: 10.1002/epi4.12056
Abstract: Epilepsy associated with cavernous malformation (CM) often requires surgical resection of seizure focus to achieve seizure‐free outcome. High‐frequency oscillations (HFOs) in intracranial electroencephalogram (EEG) are reported as potential biomarkers of epileptogenic regions, but to our… read more here.
Keywords: epilepsy; seizure free; report; seizure ... See more keywords