Early Seizure Prophylaxis in Mild and Moderate Traumatic Brain Injury: A Systematic Review and Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.0689
Abstract: Importance Guidelines recommend seizure prophylaxis for early posttraumatic seizures (PTS) after severe traumatic brain injury (TBI). Use of antiseizure medications for early seizure prophylaxis after mild or moderate TBI remains controversial. Objective To determine the… read more here.
Keywords: analysis; mild moderate; seizure; tbi ... See more keywords
Association of New-Onset Seizures With SARS-CoV-2 Vaccines: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2024.0967
Abstract: Importance Seizures have been reported as an adverse effect of the SARS-CoV-2 vaccine. However, no study has answered the question of whether there is any association between seizures in the general population and COVID-19 vaccination.… read more here.
Keywords: sars cov; new onset; seizure; vaccine ... See more keywords
Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long‐term
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51620
Abstract: Recently, we showed that resection of at least 27% of the temporal part of piriform cortex (PiC) strongly correlated with seizure freedom 1 year following selective amygdalo‐hippocampectomy (tsSAHE) in patients with mesial temporal lobe epilepsy (mTLE).… read more here.
Keywords: long term; seizure; piriform cortex; temporal lobe ... See more keywords
Pulvinar neuromodulation for seizure monitoring and network modulation in temporal plus epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of clinical and translational neurology"
DOI: 10.1002/acn3.51815
Abstract: Deep brain stimulation (DBS) is a promising treatment for drug-refractory epilepsies (DRE) when targeting the anterior nuclei of thalamus (ANT). However, targeting other thalamic nuclei, such as the pulvinar, shows therapeutic promise. Our pioneering case… read more here.
Keywords: seizure; network modulation; pulvinar; temporal plus ... See more keywords
Is seizure frequency variance a predictable quantity?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.519
Abstract: There is currently no formal method for predicting the range expected in an individual's seizure counts. Having access to such a prediction would be of benefit for developing more efficient clinical trials, but also for… read more here.
Keywords: neurology; seizure frequency; variance predictable; predictable quantity ... See more keywords
The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70139
Abstract: To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. read more here.
Keywords: anti seizure; misclassifying anti; seizure; seizure medication ... See more keywords
Increased GluK1 Subunit Receptors in Corticostriatal Projection from the Anterior Cingulate Cortex Contributed to Seizure‐Like Activities
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308444
Abstract: The corticostriatal connection plays a crucial role in cognitive, emotional, and motor control. However, the specific roles and synaptic transmissions of corticostriatal connection are less studied, especially the corticostriatal transmission from the anterior cingulate cortex… read more here.
Keywords: anterior cingulate; like activities; seizure; corticostriatal connection ... See more keywords
Subicular Astrocytes Govern Seizure-Impaired Fear Memory.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202510818
Abstract: The mechanisms underlying seizure-associated cognitive impairment remain incompletely characterized. Emerging evidence positions the subiculum, a hippocampal output hub critically involved in both epileptic seizure and cognitive performance, as a putative nexus for this comorbidity. Here,… read more here.
Keywords: memory; subicular astrocytes; fear memory; seizure ... See more keywords
Development and validation of forecasting next reported seizure using e-diaries.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of neurology"
DOI: 10.1002/ana.25812
Abstract: OBJECTIVE There are no validated methods for predicting the timing of seizures. Using machine learning, we sought to forecast 24-hour risk of self-reported seizure from e-diaries. METHODS Data from 5,419 patients of SeizureTracker.com (including seizure… read more here.
Keywords: development validation; brier score; seizure; reported seizure ... See more keywords
Comparing seizure-related death and suicide in younger adults with epilepsy.
Sign Up to like & getrecommendations! Published in 2021 at "Annals of neurology"
DOI: 10.1002/ana.26227
Abstract: Younger adults with epilepsy have an increased mortality. Some deaths are seizure-related, e.g. sudden unexpected death in epilepsy (SUDEP), while others, e.g. suicide, have multiple causes including adverse effects of the treatment on mood. In… read more here.
Keywords: death; related death; adults epilepsy; younger adults ... See more keywords
CRISPR-based KCC2 upregulation attenuates drug-resistant seizure in mouse models of epilepsy.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26656
Abstract: OBJECTIVE Precise intervention of K-Cl cotransporter isoform 2 (KCC2) as a promising target for drug-resistant epilepsy remains elusive. METHODS Here, we employed a CRISPRa system delivered by adeno-associated viruses (AAV) to specifically upregulate KCC2 in… read more here.
Keywords: epilepsy; kcc2 upregulation; seizure; drug resistant ... See more keywords