Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates
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DOI: 10.1002/epi4.70020
Abstract: To study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by… read more here.
Keywords: seizure density; pre phenobarbital; efficacy phenobarbital; mild moderate ... See more keywords
Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures
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DOI: 10.1007/s12028-022-01459-6
Abstract: Pregabalin (PGB) is an effective adjunctive treatment for focal epilepsy and acts by binding to the alpha2-delta subunit of voltage-gated calcium channels to reduce excitatory neurotransmitter release. Limited data exist on its use in the… read more here.
Keywords: seizure burden; recurrent seizures; hourly seizure; cyclic seizures ... See more keywords
Pharmacokinetic and pharmacodynamic data from the NEOLEV1 and NEOLEV2 studies
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DOI: 10.1136/archdischild-2022-324952
Abstract: Objectives To confirm that levetiracetam (LEV) demonstrates predictable pharmacokinetics(PK) at higher doses and to study the pharmacodynamics(PD) of LEV. Design Pharmacokinetic data from the NEOLEV1 and NEOLEV2 trials were analysed using a non-linear mixed effects… read more here.
Keywords: neolev2 patients; seizure burden; data neolev1; neolev1 neolev2 ... See more keywords
Seizure Burden Before and After Lidocaine as Add-on Therapy in (a)EEG-Confirmed Neonatal Seizures.
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DOI: 10.1159/000549690
Abstract: Introduction The primary aim of this study was to evaluate the total seizure burden (TSB) and maximum hourly seizure burden (MSB) before and after the administration of lidocaine (LDC) as add-on therapy in neonates with… read more here.
Keywords: etiology; seizure burden; seizure; eeg confirmed ... See more keywords
Seizure Burden and Neurologic Outcomes After Neonatal Encephalopathy
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DOI: 10.1212/wnl.0000000000207202
Abstract: Background and Objectives Seizures are common during neonatal encephalopathy (NE), but the contribution of seizure burden (SB) to outcomes remains controversial. This study aims to examine the relationship between electrographic SB and neurologic outcomes after… read more here.
Keywords: seizure burden; neurologic outcomes; brain; neonatal encephalopathy ... See more keywords
Accuracy of a Rapid-Response EEG's Automated Seizure-Burden Estimator
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DOI: 10.1212/wnl.0000000000210234
Abstract: Background and Objectives The use of rapid response EEG (rr-EEG) has recently expanded in limited-resource settings and as a supplement to conventional EEG to rapidly detect and treat nonconvulsive status epilepticus. The study objective was… read more here.
Keywords: seizure burden; rapid response; eeg; ese pese ... See more keywords