Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long‐term, open‐label, repeat‐dose safety study
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DOI: 10.1002/epi4.12494
Abstract: Need for rescue therapy differs among patients with seizure clusters. Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age. This analysis used interim data from a phase… read more here.
Keywords: patients seizure; diazepam nasal; safety; seizure clusters ... See more keywords
Updated review of rescue treatments for seizure clusters and prolonged seizures
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DOI: 10.1080/14737175.2022.2105207
Abstract: ABSTRACT Introduction Although the treatment of epilepsy primarily focuses on prevention, recurrent seizures are unfortunately an ongoing reality, particularly in people with epilepsy who live with chronic refractory seizures. Rescue medications are agents which can… read more here.
Keywords: rescue; rescue medications; clusters prolonged; prolonged seizures ... See more keywords
Rescue therapies in epilepsy
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DOI: 10.1097/wco.0000000000001038
Abstract: Purpose of review The purpose of this review is to provide a succinct evaluation of the current rescue medications and action plans available to our patients with seizure clusters in the outpatient setting. Recent findings… read more here.
Keywords: rescue therapies; rescue; rescue medications; seizure clusters ... See more keywords
Economic aspects of treating seizure clusters
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DOI: 10.1111/epi.17340
Abstract: Seizure clusters may initiate a chain of events that have economic as well as clinical consequences. The potential economic consequences of seizure clusters must be weighed against the cost of medication to attenuate them. This… read more here.
Keywords: seizure; treating seizure; economic aspects; aspects treating ... See more keywords
Rescue therapies for seizure clusters: Pharmacology and target of treatments
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DOI: 10.1111/epi.17341
Abstract: The primary goal of treatment for seizure clusters is cessation of the cluster to avoid progression to more severe conditions, such as prolonged seizures and status epilepticus. Rescue therapies are key components of treatment plans… read more here.
Keywords: rescue therapies; pharmacology; therapies seizure; seizure clusters ... See more keywords
Consequences: Bench to home
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DOI: 10.1111/epi.17342
Abstract: Seizure clusters (also referred to as acute repetitive seizures) consist of several seizures interspersed with brief interictal periods. Seizure clusters can break down γ‐aminobutyric acidergic (GABAergic) inhibition of dentate granule cells, leading to hyperactivation. Functional… read more here.
Keywords: seizure; consequences bench; bench home; treatment ... See more keywords
Seizure clusters: Practical aspects and clinical strategies to care for patients in the community
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DOI: 10.1111/epi.17345
Abstract: Seizure clusters are a serious, yet often underdiagnosed and inadequately treated, occurrence in people with epilepsy. A challenge for both health care providers and patients is the lack of a cohesive integrated body of information… read more here.
Keywords: health; seizure; care; people epilepsy ... See more keywords
Recognizing seizure clusters in the community: The path to uniformity and individualization in nomenclature and definition
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DOI: 10.1111/epi.17346
Abstract: Seizure emergencies experienced by patients with epilepsy include status epilepticus and seizure clusters. Although an accepted definition of status epilepticus exists, no clear consensus definition of seizure clusters has emerged; this is further complicated by… read more here.
Keywords: definition; seizure; status epilepticus; cluster ... See more keywords
Forecasting seizure clusters from chronic ambulatory electrocorticography
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DOI: 10.1111/epi.17347
Abstract: Seizure clusters are seizures that occur in rapid succession during periods of heightened seizure risk and are associated with substantial morbidity and sudden unexpected death in epilepsy. The objective of this feasibility study was to… read more here.
Keywords: seizure; forecasting seizure; ambulatory electrocorticography; chronic ambulatory ... See more keywords
Future opportunities for research in rescue treatments
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DOI: 10.1111/epi.17363
Abstract: Clinical studies of rescue medications for seizure clusters are limited and are designed to satisfy regulatory requirements, which may not fully consider the needs of the diverse patient population that experiences seizure clusters or utilize… read more here.
Keywords: seizure; seizure cluster; research; future opportunities ... See more keywords
Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters
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DOI: 10.1111/epi.17385
Abstract: Intermittent rescue therapy may be used for seizure clusters, which are clinical emergencies that may persist ≥24 h and increase risk of status epilepticus, emergency room visits, and reduced quality of life for patients with epilepsy.… read more here.
Keywords: time; seizure; intermittent rescue; rescue therapy ... See more keywords