Is seizure frequency variance a predictable quantity?
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.519
Abstract: There is currently no formal method for predicting the range expected in an individual's seizure counts. Having access to such a prediction would be of benefit for developing more efficient clinical trials, but also for… read more here.
Keywords: neurology; seizure frequency; variance predictable; predictable quantity ... See more keywords
Efficacy and Safety of Adjunctive Cannabidiol in Patients with Lennox–Gastaut Syndrome: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2018 at "CNS Drugs"
DOI: 10.1007/s40263-018-0558-9
Abstract: AbstractBackgroundLennox–Gastaut syndrome (LGS) is a severe developmental epileptic encephalopathy, and available interventions fail to control seizures in most patients. Cannabidiol (CBD) is a major chemical of marijuana, which has anti-seizure properties and different mechanisms of… read more here.
Keywords: cbd; efficacy safety; seizure frequency; gastaut syndrome ... See more keywords
Letter to the editor: Reducing seizure frequency in patients with refractory epilepsy with cathodal transcranial direct current stimulation
Sign Up to like & getrecommendations! Published in 2021 at "Brain Stimulation"
DOI: 10.1016/j.brs.2021.07.014
Abstract: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive… read more here.
Keywords: seizure frequency; stimulation; editor reducing; reducing seizure ... See more keywords
Does accounting for seizure frequency variability increase clinical trial power?
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2017.07.013
Abstract: OBJECTIVE Seizure frequency variability is associated with placebo responses in randomized controlled trials (RCT). Increased variability can result in drug misclassification and, hence, decreased statistical power. We investigated a new method that directly incorporated variability… read more here.
Keywords: seizure frequency; power; frequency variability; variability ... See more keywords
Higher transcription alleles of the MAOA-uVNTR polymorphism are associated with higher seizure frequency in temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2018.11.003
Abstract: BACKGROUND There is evidence of an imbalance in the neuromodulatory system mediated by serotonin (5-HT) in patients with drug-resistant temporal lobe epilepsy (TLE). This study analyzed the monoamine oxidase A promoter variable number of tandem… read more here.
Keywords: lobe epilepsy; seizure frequency; maoa uvntr; uvntr polymorphism ... See more keywords
Pregnant women with more seizures have lower allopregnanolone concentrations
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2021.106778
Abstract: Neuroactive steroids have rapid, nongenomic effects on neuronal excitability. The effects in humans are less clear. We compared seizure control and concentrations of neuroactive steroids, known to influence neuroexcitability in animal studies, in pregnant women.… read more here.
Keywords: seizure frequency; frequency; pregnant women; allopregnanolone concentrations ... See more keywords
Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.10.012
Abstract: Status epilepticus (SE) triggers a myriad of neurological alterations that include unprovoked seizures, temporal lobe epilepsy (TLE), and cognitive deficits. Although SE-induced loss of hippocampal dendritic structures and synaptic remodeling are often associated with this… read more here.
Keywords: epilepsy; epilepticus triggers; seizure frequency; c1q ... See more keywords
Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2017.10.003
Abstract: Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin. The importance of continued administration of imepitoin in these dogs… read more here.
Keywords: seizure frequency; imepitoin phenobarbital; imepitoin; withdrawal ... See more keywords
Seizure frequency in patients with isolated subdural hematoma and preserved consciousness
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DOI: 10.1080/02699052.2019.1606446
Abstract: ABSTRACT Background: Seizures are a complication of subdural hematoma (SDH), and there is substantial variability in the use of seizure prophylaxis for patients with SDH. However, the incidence of seizures in patients with SDH without… read more here.
Keywords: seizure frequency; seizure; subdural hematoma; patients isolated ... See more keywords
Extracting seizure frequency from epilepsy clinic notes: a machine reading approach to natural language processing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Medical Informatics Association : JAMIA"
DOI: 10.1093/jamia/ocac018
Abstract: Abstract Objective Seizure frequency and seizure freedom are among the most important outcome measures for patients with epilepsy. In this study, we aimed to automatically extract this clinical information from unstructured text in clinical notes.… read more here.
Keywords: seizure frequency; reading approach; seizure; extracting seizure ... See more keywords
Proton MR Spectroscopy in Patients With Sleep-Related Hypermotor Epilepsy (SHE): Evidence of Altered Cingulate Cortex Metabolism
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DOI: 10.1093/sleep/zsx115
Abstract: Study Objectives To identify structural and/or metabolic alterations in patients with sleep-related hypermotor epilepsy (SHE) using magnetic resonance imaging (MRI) and proton MR spectroscopy (1H-MRS). Methods Nineteen SHE patients (seven males; 34.7 ± 9.7 years,… read more here.
Keywords: patients sleep; seizure frequency; sleep related; cingulate cortex ... See more keywords