Optimization of a locomotion-based zebrafish seizure model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Methods"
DOI: 10.1016/j.jneumeth.2022.109594
Abstract: BACKGROUND Locomotor assays in zebrafish have emerged as a screening test in early drug discovery for antiseizure compounds. However, parameters differ considerably between published studies, which may explain some discrepant results with (candidate) antiseizure medications.… read more here.
Keywords: ptz; ptz induced; seizure model; locomotion ... See more keywords
Evaluation of caffeine modulation of topiramate effect on locomotor activity of zebrafish larvae in pentylenetetrazol-induced seizure model
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0317241
Abstract: Epilepsy is a prevalent neurological condition marked by seizures that lead to neurobiological and behavioral impairments. Caffeine (CAF), the world’s most consumed stimulant, reportedly affects both epileptic seizures and the efficacy of antiepileptic drugs, particularly… read more here.
Keywords: larvae; seizure model; induced seizure; activity ... See more keywords
Caffeine Decreases Topiramate Levels in Zebrafish Larvae in a Pentylenetetrazol-Induced Seizure Model
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25063309
Abstract: Epilepsy ranks as the second-most prevalent neurological disease, and is characterized by seizures resulting in neurobiological and behavioral impairment. Naturally occurring in coffee beans or tea leaves, the alkaloid caffeine (CAF) is the most prevalent… read more here.
Keywords: zebrafish larvae; seizure model; tpm; induced seizure ... See more keywords