Expression Pattern of ALOXE3 in Mouse Brain Suggests Its Relationship with Seizure Susceptibility.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and molecular neurobiology"
DOI: 10.1007/s10571-020-00974-4
Abstract: Arachidonic acid (AA), a polyunsaturated fatty acid, is involved in the modulation of neuronal excitability in the brain. Arachidonate lipoxygenase 3 (ALOXE3), a critical enzyme in the AA metabolic pathway, catalyzes the derivate of AA… read more here.
Keywords: pattern aloxe3; expression; seizure susceptibility; expression pattern ... See more keywords
Increase in seizure susceptibility in sepsis like condition explained by spiking cytokines and altered adhesion molecules level with impaired blood brain barrier integrity in experimental model of rats treated with lipopolysaccharides
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2017.05.012
Abstract: BACKGROUND AND OBJECTIVE Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Sepsis is a condition which initiates a cascade of a surge of inflammatory mediators. Interplay between seizures and inflammation other than of… read more here.
Keywords: sepsis; blood brain; sepsis like; brain barrier ... See more keywords
Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.113994
Abstract: The adhesion G protein-coupled receptor BAI1/ADGRB1 plays an important role in suppressing angiogenesis, mediating phagocytosis, and acting as a brain tumor suppressor. BAI1 is also a critical regulator of dendritic spine and excitatory synapse development… read more here.
Keywords: seizure susceptibility; adgrb1; mice; full length ... See more keywords
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2017.07.006
Abstract: Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive neurological deterioration. While several genetic causes for PMEs have been identified, the underlying causes remain unknown for a substantial portion of… read more here.
Keywords: gpr37l1; seizure susceptibility; gpr37l1 variant; evidence ... See more keywords
RETRACTED: Nicotinic acetylcholine receptor α7 subunit maybe a risk factor of seizure susceptibility
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.03.053
Abstract: Previous studies have confirmed that α7 nicotinic acetylcholine receptors (nAChRs) play a pivotal role in cognition, memory, and neuropsychiatric diseases, but their effect on seizure susceptibility is not fully understood. Here, we show that decreased… read more here.
Keywords: maybe risk; nicotinic acetylcholine; risk factor; seizure susceptibility ... See more keywords
Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio.
Sign Up to like & getrecommendations! Published in 2020 at "Cerebral cortex"
DOI: 10.1093/cercor/bhaa157
Abstract: Chronic symptoms indicating excess cortical excitability follow mild traumatic brain injury, particularly repetitive mild traumatic brain injury (rmTBI). Yet mechanisms underlying post-traumatic excitation/inhibition (E/I) ratio abnormalities may differ between the early and late post-traumatic phases.… read more here.
Keywords: rmtbi; parvalbumin positive; glu; seizure susceptibility ... See more keywords
Synaptic Zn2+ and febrile seizure susceptibility
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13658
Abstract: Zn2+, the second most prevalent trace element in the body, is essential for supporting a wide range of biological functions. While the majority of Zn2+ in the brain is protein‐bound, a significant proportion of free… read more here.
Keywords: seizure susceptibility; zn2; febrile seizure; synaptic zn2 ... See more keywords
TNFα-mediated necroptosis in brain endothelial cells as a potential mechanism of increased seizure susceptibility in mice following systemic inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-022-02406-0
Abstract: Background Systemic inflammation is a potent contributor to increased seizure susceptibility. However, information regarding the effects of systemic inflammation on cerebral vascular integrity that influence neuron excitability is scarce. Necroptosis is closely associated with inflammation… read more here.
Keywords: seizure susceptibility; systemic inflammation; susceptibility; brain ... See more keywords
Activation of Calcium-Activated Chloride Channels Suppresses Inherited Seizure Susceptibility in Genetically Epilepsy-Prone Rats
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020449
Abstract: Inherited seizure susceptibility in genetically epilepsy-prone rats (GEPR-3s) is associated with increased voltage-gated calcium channel currents suggesting a massive calcium influx resulting in increased levels of intraneuronal calcium. Cytosolic calcium, in turn, activates many processes,… read more here.
Keywords: seizure; seizure susceptibility; genetically epilepsy; calcium ... See more keywords
Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10051138
Abstract: Objectives: We investigated whether seizure susceptibility increases over weeks–months after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats predicts the development of post-traumatic epilepsy (PTE) or epileptiform activity. We further investigated whether… read more here.
Keywords: seizure; sleep disturbance; seizure susceptibility; number ... See more keywords
Degrading Seizures (or, Playing Tag with Nedd4-2)
Sign Up to like & getrecommendations! Published in 2017 at "Epilepsy Currents"
DOI: 10.5698/1535-7597.17.4.241
Abstract: Commentary Tightly regulated protein homeostasis is essential for neuronal function. In response to external stimuli, proteins are constantly added to and removed from synapses. The dynamic regulation of synaptic and neuronal protein content is achieved… read more here.
Keywords: protein; epilepsy; nedd4; degrading seizures ... See more keywords