A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46644-7
Abstract: Proteasome subunit hRpn13 is partially proteolyzed in certain cancer cell types to generate hRpn13Pru by degradation of its UCHL5/Uch37-binding DEUBAD domain and retention of an intact proteasome- and ubiquitin-binding Pru domain. By using structure-guided virtual… read more here.
Keywords: select group; ken box; structure; box proteins ... See more keywords
As you sow, so shall you reap: Understanding the social-emotional development of a select group of Filipino grandchildren reared by grandparent educators
Sign Up to like & getrecommendations! Published in 2018 at "Educational Gerontology"
DOI: 10.1080/03601277.2018.1520532
Abstract: ABSTRACT In light of new family structures and patterns that continue to emerge in contemporary society, grandparents are delegated with a more active role in child-rearing, particularly during the crucial stages of their grandchildren’s development.… read more here.
Keywords: emotional development; group filipino; select group; development ... See more keywords