Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300738
Abstract: Inflammation induced by autoreactive CD4+ T lymphocytes is a major factor in the pathogenesis of multiple sclerosis (MS). Immunosuppressive drugs, such as FTY720, are subsequently developed to prevent the migration of CD4+ T lymphocytes to… read more here.
Keywords: selectin; immunosuppressive drugs; lymph nodes; treatment ... See more keywords
Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study
Sign Up to like & getrecommendations! Published in 2017 at "Lung"
DOI: 10.1007/s00408-017-0029-y
Abstract: PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed… read more here.
Keywords: cystic fibrosis; svcam selectin; study; selectin ... See more keywords
PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level
Sign Up to like & getrecommendations! Published in 2017 at "Inflammation"
DOI: 10.1007/s10753-017-0711-5
Abstract: Abstract L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) are adhesion molecules which induce similar physiological events. Our previous paper showed that phosphatidylinositol 3-kinase (PI3K) played a crucial role in L-selectin- and PSGL-1-mediated F-actin redistribution and assembly… read more here.
Keywords: pi3k; linker selectin; level; selectin psgl ... See more keywords
L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "3 Biotech"
DOI: 10.1007/s13205-020-02549-y
Abstract: L-selectin is a cell adhesion molecule that plays an important role in modulating immune cell trafficking. The expression of L-selectin has been found to be upregulated in several human cancers. However, the association of L-selectin… read more here.
Keywords: expression; selectin; sell expression; breast cancer ... See more keywords
Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "JACC: Basic to Translational Science"
DOI: 10.1016/j.jacbts.2021.09.013
Abstract: COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of inflammation released by endothelial cells. We tested the effect of P-selectin inhibition on biomarkers of thrombosis and inflammation in patients… read more here.
Keywords: selectin; selectin inhibitor; crizanlizumab selectin; effect ... See more keywords
Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2016.11.007
Abstract: &NA; Obesity‐induced insulin resistance and metabolic syndrome continue to pose an important public health challenge worldwide as they significantly increase the risk of type 2 diabetes and atherosclerotic cardiovascular disease. Advances in the pathophysiologic understanding… read more here.
Keywords: selectin interactions; psgl selectin; glycoprotein ligand; metabolic syndrome ... See more keywords
Biomarkers in cancer patients at risk for venous thromboembolism: data from the AVERT study.
Sign Up to like & getrecommendations! Published in 2020 at "Thrombosis research"
DOI: 10.1016/s0049-3848(20)30394-7
Abstract: BACKGROUND The mechanisms surrounding cancer-associated venous thromboembolism (VTE) are not well characterized. AVERT, a randomized placebo controlled thromboprophylaxis study in ambulatory cancer patients, provides a unique opportunity to gain insights into thrombotic mechanism(s). METHODS All… read more here.
Keywords: study; venous thromboembolism; cancer; cancer patients ... See more keywords
Rational Design of Novel Glycomimetic Peptides for E-Selectin Targeting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00295
Abstract: E-selectin is a cell-adhesion receptor with specific recognition capacity toward sialo-fucosylated Lewis carbohydrates present in leukocytes and tumor cells. E-selectin interactions mediate the progress of inflammatory processes and tumor metastasis, which aroused the interest in… read more here.
Keywords: selectin targeting; novel glycomimetic; glycomimetic peptides; selectin binding ... See more keywords
Novartis snaps up Selexys for sickle cell
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt0217-106
Abstract: A monoclonal antibody targeting the adhesion protein P-selectin halved the annual rate of painful blood vessel blockages in patients with sickle cell disease in a phase 2 trial. The positive data prompted Basel-based Novartis to… read more here.
Keywords: cell; cell disease; sickle cell; selectin ... See more keywords
Sialyl Lewisx-P-selectin cascade mediates tumor–mesothelial adhesion in ascitic fluid shear flow
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10334-6
Abstract: Organ-specific colonization suggests that specific cell–cell recognition is essential. Yet, very little is known about this particular interaction. Moreover, tumor cell lodgement requires binding under shear stress, but not static, conditions. Here, we successfully isolate… read more here.
Keywords: selectin cascade; fluid shear; lewisx selectin; sialyl lewisx ... See more keywords
P-selectin, endocan, and some adhesion molecules in obese children and adolescents with non-alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2017.1292363
Abstract: Abstract There is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived… read more here.
Keywords: alcoholic fatty; fatty liver; non alcoholic; adhesion ... See more keywords