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   Articles with "selectin" as a keyword



E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

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recommendations! Published in 2024 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13733

Abstract: Colorectal cancer (CRC) cells express sialylated Lewis antigens (sLe), crucial for metastasis via E‐selectin binding. However, these glycoepitopes lack cancer specificity, and E‐selectin‐targeted glycoproteins remain largely unknown. Here, we established a framework for identifying metastasis‐linked… read more here.

Keywords: poor prognosis; colorectal cancer; cancer; selectin ... See more keywords

Hierarchical Precision Nanoplatform for Synergistic Radio‐Immunotherapy in Glioblastoma via Controllable P‐Selectin Targeting

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recommendations! Published in 2025 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202516391

Abstract: The combination of radiotherapy and immune checkpoint blockade (ICB) therapy has demonstrated considerable efficacy in oncological treatment. However, the clinical PD‐L1 antibody (anti‐PD‐L1) for glioblastoma (GBM) imprecisely accumulated in intracranial radiotherapy target and is often… read more here.

Keywords: selectin; glioblastoma; hierarchical precision; nanoplatform ... See more keywords

Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.

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recommendations! Published in 2023 at "Advanced science"

DOI: 10.1002/advs.202300738

Abstract: Inflammation induced by autoreactive CD4+ T lymphocytes is a major factor in the pathogenesis of multiple sclerosis (MS). Immunosuppressive drugs, such as FTY720, are subsequently developed to prevent the migration of CD4+ T lymphocytes to… read more here.

Keywords: selectin; immunosuppressive drugs; lymph nodes; treatment ... See more keywords

Increased Soluble VCAM-1 and Normal P-Selectin in Cystic Fibrosis: a Cross-Sectional Study

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recommendations! Published in 2017 at "Lung"

DOI: 10.1007/s00408-017-0029-y

Abstract: PurposeAs life expectancy in cystic fibrosis (CF) increases, questions regarding its potential impact on cardiovascular health arise. Soluble vascular cell adhesion molecule 1 (sVCAM-1), P-selectin (sP-selectin) are proposed as biomarkers of cardiovascular disease. We aimed… read more here.

Keywords: cystic fibrosis; svcam selectin; study; selectin ... See more keywords

PI3K Is a Linker Between L-selectin and PSGL-1 Signaling to IL-18 Transcriptional Activation at the Promoter Level

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recommendations! Published in 2017 at "Inflammation"

DOI: 10.1007/s10753-017-0711-5

Abstract: Abstract L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) are adhesion molecules which induce similar physiological events. Our previous paper showed that phosphatidylinositol 3-kinase (PI3K) played a crucial role in L-selectin- and PSGL-1-mediated F-actin redistribution and assembly… read more here.

Keywords: pi3k; linker selectin; level; selectin psgl ... See more keywords
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L-Selectin expression is associated with inflammatory microenvironment and favourable prognosis in breast cancer

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recommendations! Published in 2021 at "3 Biotech"

DOI: 10.1007/s13205-020-02549-y

Abstract: L-selectin is a cell adhesion molecule that plays an important role in modulating immune cell trafficking. The expression of L-selectin has been found to be upregulated in several human cancers. However, the association of L-selectin… read more here.

Keywords: expression; selectin; sell expression; breast cancer ... See more keywords

Effect of Crizanlizumab, a P-Selectin Inhibitor, in COVID-19

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recommendations! Published in 2021 at "JACC: Basic to Translational Science"

DOI: 10.1016/j.jacbts.2021.09.013

Abstract: COVID-19 is characterized by vascular inflammation and thrombosis, including elevations in P-selectin, a mediator of inflammation released by endothelial cells. We tested the effect of P-selectin inhibition on biomarkers of thrombosis and inflammation in patients… read more here.

Keywords: selectin; selectin inhibitor; crizanlizumab selectin; effect ... See more keywords

Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome

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recommendations! Published in 2017 at "Translational Research"

DOI: 10.1016/j.trsl.2016.11.007

Abstract: &NA; Obesity‐induced insulin resistance and metabolic syndrome continue to pose an important public health challenge worldwide as they significantly increase the risk of type 2 diabetes and atherosclerotic cardiovascular disease. Advances in the pathophysiologic understanding… read more here.

Keywords: selectin interactions; psgl selectin; glycoprotein ligand; metabolic syndrome ... See more keywords
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Biomarkers in cancer patients at risk for venous thromboembolism: data from the AVERT study.

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recommendations! Published in 2020 at "Thrombosis research"

DOI: 10.1016/s0049-3848(20)30394-7

Abstract: BACKGROUND The mechanisms surrounding cancer-associated venous thromboembolism (VTE) are not well characterized. AVERT, a randomized placebo controlled thromboprophylaxis study in ambulatory cancer patients, provides a unique opportunity to gain insights into thrombotic mechanism(s). METHODS All… read more here.

Keywords: study; venous thromboembolism; cancer; cancer patients ... See more keywords
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Rational Design of Novel Glycomimetic Peptides for E-Selectin Targeting

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recommendations! Published in 2021 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.1c00295

Abstract: E-selectin is a cell-adhesion receptor with specific recognition capacity toward sialo-fucosylated Lewis carbohydrates present in leukocytes and tumor cells. E-selectin interactions mediate the progress of inflammatory processes and tumor metastasis, which aroused the interest in… read more here.

Keywords: selectin targeting; novel glycomimetic; glycomimetic peptides; selectin binding ... See more keywords
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Novartis snaps up Selexys for sickle cell

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recommendations! Published in 2017 at "Nature Biotechnology"

DOI: 10.1038/nbt0217-106

Abstract: A monoclonal antibody targeting the adhesion protein P-selectin halved the annual rate of painful blood vessel blockages in patients with sickle cell disease in a phase 2 trial. The positive data prompted Basel-based Novartis to… read more here.

Keywords: cell; cell disease; sickle cell; selectin ... See more keywords