Rational Design of Novel Glycomimetic Peptides for E-Selectin Targeting
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c00295
Abstract: E-selectin is a cell-adhesion receptor with specific recognition capacity toward sialo-fucosylated Lewis carbohydrates present in leukocytes and tumor cells. E-selectin interactions mediate the progress of inflammatory processes and tumor metastasis, which aroused the interest in… read more here.
Keywords: selectin targeting; novel glycomimetic; glycomimetic peptides; selectin binding ... See more keywords
Early in vitro results indicate that de-O-acetylated sialic acids increase Selectin binding in cancers
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2024.1443303
Abstract: Cancers utilize a simple glycan, Sialic Acid, to engage in metastatic processes via the Sialic acid (Sia) -Selectin pathway. Selectins recognize and bind to sialylated substrates, resulting in adhesion, migration, and extravasation, however, how deviations… read more here.
Keywords: selectin; selectin binding; sialic acid; acetylated sia ... See more keywords