Targeting SELPLG/P‐selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter
Sign Up to like & getrecommendations! Published in 2023 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12206
Abstract: Abstract We previously identified a missense single nucleotide polymorphism rs2228315 (G>A, Met62Ile) in the selectin‐P‐ligand gene (SELPLG), encoding P‐selectin glycoprotein ligand 1 (PSGL‐1), to be associated with increased susceptibility to acute respiratory distress syndrome (ARDS).… read more here.
Keywords: promoter; selectin glycoprotein; selplg promoter; regulation ... See more keywords
Circulating P-Selectin and Its Glycoprotein Ligand in Nondiabetic Obstructive Sleep Apnea Patients.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2020_501
Abstract: Selectins and their ligands play an important role in atherosclerosis. The role of these adhesion molecules in the pathogenesis of obstructive sleep apnea (OSA) may be of clinical relevance. Therefore, the aim of this study… read more here.
Keywords: obstructive sleep; osa; apnea; glycoprotein ligand ... See more keywords
Targeting P‐selectin glycoprotein ligand‐1/P‐selectin interactions as a novel therapy for metabolic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Translational Research"
DOI: 10.1016/j.trsl.2016.11.007
Abstract: &NA; Obesity‐induced insulin resistance and metabolic syndrome continue to pose an important public health challenge worldwide as they significantly increase the risk of type 2 diabetes and atherosclerotic cardiovascular disease. Advances in the pathophysiologic understanding… read more here.
Keywords: selectin interactions; psgl selectin; glycoprotein ligand; metabolic syndrome ... See more keywords
A Soluble Form of P Selectin Glycoprotein Ligand 1 Requires Signaling by Nuclear Factor Erythroid 2–Related Factor 2 to Protect Liver Transplant Endothelial Cells Against Ischemia–Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14159
Abstract: Liver endothelial cell (LEC) damage is essential in the pathogenesis of ischemia–reperfusion injury (IRI) in transplant recipients. We analyzed the mechanism of LEC resistance against IRI by using a novel recombinant soluble form of P… read more here.
Keywords: liver; glycoprotein ligand; selectin glycoprotein; ischemia reperfusion ... See more keywords
Myeloid Mineralocorticoid Receptor Transcriptionally Regulates P-Selectin Glycoprotein Ligand-1 and Promotes Monocyte Trafficking and Atherosclerosis
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316929
Abstract: Supplemental Digital Content is available in the text. Objective: MR (mineralocorticoid receptor) activation associates with increased risk of cardiovascular ischemia while MR inhibition reduces cardiovascular-related mortality and plaque inflammation in mouse atherosclerosis. MR in myeloid… read more here.
Keywords: mineralocorticoid receptor; myeloid; atherosclerosis; glycoprotein ligand ... See more keywords
P-Selectin Glycoprotein Ligand 1: A Potential HIV-1 Therapeutic Target
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.710121
Abstract: Antiretroviral therapy (ART), which is a life-long therapeutic option, remains the only currently effective clinical method to treat HIV-1 infection. However, ART may be toxic to vital organs including the liver, brain, heart, and kidneys,… read more here.
Keywords: potential hiv; hiv; ligand potential; glycoprotein ligand ... See more keywords