VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00638g
Abstract: To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works… read more here.
Keywords: vivo selection; selection assay; vitas sensitive; sensitive vivo ... See more keywords
Development of a selection assay for small guide RNAs that drive efficient site-directed RNA editing
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad098
Abstract: Abstract A major challenge confronting the clinical application of site-directed RNA editing (SDRE) is the design of small guide RNAs (gRNAs) that can drive efficient editing. Although many gRNA designs have effectively recruited endogenous Adenosine… read more here.
Keywords: rna editing; site directed; selection assay; directed rna ... See more keywords