Mathematical modeling of lymphocytes selection in the germinal center
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DOI: 10.1007/s00285-016-1038-9
Abstract: Lymphocyte selection is a fundamental process of adaptive immunity. In order to produce B-lymphocytes with a target antigenic profile, mutation selection and division occur in the germinal center, a specific part of lymph nodes. We… read more here.
Keywords: germinal center; selection germinal; mathematical modeling; lymphocytes selection ... See more keywords
From affinity selection to kinetic selection in Germinal Centre modelling
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DOI: 10.1371/journal.pcbi.1010168
Abstract: Affinity maturation is an evolutionary process by which the affinity of antibodies (Abs) against specific antigens (Ags) increases through rounds of B-cell proliferation, somatic hypermutation, and positive selection in germinal centres (GC). The positive selection… read more here.
Keywords: cell; selection germinal; affinity; dissociation rates ... See more keywords