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Published in 2017 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1290650
Abstract: ABSTRACT In the two-stage continual reassessment method (CRM), model-based dose escalation is preceded by a pre-specified escalating sequence starting from the lowest dose level. This is appealing to clinicians because it allows a sufficient number…
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Keywords:
selection initial;
initial design;
design two;
two stage ... See more keywords