RNA-ALIS: Methodology for screening soluble RNAs as small molecule targets using ALIS affinity-selection mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2019.04.024
Abstract: Recent advances resulting from the completion of the human genome have shown that RNA has the promise to be a target for small molecule drugs, and therefore represents a previously unexploited class of targets for… read more here.
Keywords: affinity selection; methodology; small molecule; selection mass ... See more keywords
Discovery of CD28-Targeted Small Molecule Inhibitors of T Cell Co-Stimulation Using Affinity Selection-Mass Spectrometry (AS-MS) and Ex Vivo Validation.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02136
Abstract: CD28 is a key T cell costimulatory receptor implicated in antitumor immunity and immune-related disorders, yet no small molecule modulators of CD28 have reached clinical development. Here, we report the discovery and characterization of small… read more here.
Keywords: cd28; affinity selection; mass spectrometry; small molecule ... See more keywords
Identification of Novel Leishmania donovani Nucleoside Hydrolase Inhibitors from Banisteriopsis laevifolia Using Affinity Selection-Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c01613
Abstract: The identification of enzyme inhibitors from natural sources offers a promising pathway for drug discovery. In this study, affinity selection-mass spectrometry (AS-MS) was employed to screen for inhibitors of Leishmania donovani nucleoside hydrolase (LdNH) from… read more here.
Keywords: affinity selection; mass spectrometry; leishmania donovani; nucleoside hydrolase ... See more keywords
Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection–Mass Spectrometry
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DOI: 10.1177/2472555218796656
Abstract: The Myc oncogene is overexpressed in many cancers, yet targeting it for cancer therapy has remained elusive. One strategy for inhibition of Myc expression is through stabilization of the G-quadruplex (G4), a G-rich DNA secondary… read more here.
Keywords: affinity selection; selection mass; mass spectrometry; myc expression ... See more keywords