Loss of the IR region in conifer plastomes: Changes in the selection pressure and substitution rate of protein‐coding genes
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.8499
Abstract: Abstract Plastid genomes (plastomes) have a quadripartite structure, but some species have drastically reduced or lost inverted repeat (IR) regions. IR regions are important for genome stability and the evolution rate. In the evolutionary process… read more here.
Keywords: rate; coding genes; selection pressure; selection ... See more keywords
The role of selection pressure in shaping zoxamide resistance in Plasmopara viticola populations
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DOI: 10.1002/ps.8890
Abstract: Zoxamide, a β‐tubulin inhibitor, is widely used in vineyards to control downy mildew caused by the high‐risk pathogen Plasmopara viticola. This study aimed to investigate the selection of zoxamide resistance and its characterization, providing practical… read more here.
Keywords: resistance; zoxamide resistance; plasmopara viticola; selection ... See more keywords
Orthogonal replication with optogenetic selection evolves yeast JEN1 into a mevalonate transporter
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Systems Biology"
DOI: 10.1038/s44320-025-00113-5
Abstract: The in vivo continuous evolution system OrthoRep (orthogonal replication) is a powerful strategy for rapid enzyme evolution in Saccharomyces cerevisiae that diversifies genes at a rate exceeding the endogenous genome mutagenesis rate by several orders… read more here.
Keywords: evolution; mevalonate; orthogonal replication; selection ... See more keywords
Assessment of selection pressure exerted on genes from complete pangenomes helps to improve the accuracy in the prediction of new genes
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac010
Abstract: Bacterial genomes are massively sequenced, and they provide valuable data to better know the complete set of genes of a species. The analysis of thousands of bacterial strains can identify both shared genes and those… read more here.
Keywords: pressure; complete pangenomes; genes complete; gene ... See more keywords
The Effect of Antibiotic Selection Pressure on the Nasopharyngeal Macrolide Resistome: A Cluster-randomized Trial
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DOI: 10.1093/cid/ciy339
Abstract: Background Frequent use of antibiotics is thought to create selection pressure by clearing susceptible bacteria and allowing resistant bacteria to spread in a community. A cluster-randomized trial comparing 2 different frequencies of mass azithromycin distributions… read more here.
Keywords: selection pressure; resistance determinants; cluster randomized; resistance ... See more keywords
Under (Genetic Selection) Pressure: Human Tumors and Human Populations in Hypoxia.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-25-0175
Abstract: Arenillas and colleagues report that pheochromocytomas and paragangliomas in the setting of chronic hypoxia due to cyanotic congenital heart disease harbor, at high frequency, somatic gain-of-function mutations in the EPAS1 gene, which encodes for one… read more here.
Keywords: genetic selection; human tumors; human populations; pressure human ... See more keywords
Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Lipid Research"
DOI: 10.1194/jlr.ra119000251
Abstract: The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a… read more here.
Keywords: chemotherapy selection; dnr; resistant cells; selection pressure ... See more keywords
The Danaid Theory of Aging
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.671208
Abstract: The classical evolutionary theories of aging suggest that aging evolves due to insufficient selective pressure against it. In these theories, declining selection pressure with age leads to aging through genes or resource allocations, implying that… read more here.
Keywords: theory; biology; theory aging; danaid theory ... See more keywords
Selection Pressure Pathways and Mechanisms of Resistance to the Demethylation Inhibitor-Difenoconazole in Penicillium expansum
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.02472
Abstract: Penicillium expansum causes blue mold, the most economically important postharvest disease of pome fruit worldwide. Beside sanitation practices, the disease is managed through fungicide applications at harvest. Difenoconazole (DIF) is a new demethylation inhibitor (DMI)… read more here.
Keywords: penicillium expansum; resistance; selection pressure; dif ... See more keywords
Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population
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DOI: 10.3390/biology11020257
Abstract: Simple Summary In this study, we developed a simple simulation model to illustrate the effects of different mating patterns on the spread of autosomal recessive deafness 1A (DFNB1A) in an isolated human population with regard… read more here.
Keywords: dfnb1a; selection pressure; deafness; selection ... See more keywords
Understanding Intratumor Heterogeneity and Evolution in NSCLC and Potential New Therapeutic Approach
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DOI: 10.3390/cancers10070212
Abstract: Advances in innovative technology, including next-generation sequencing, have allowed comprehensive genomic analysis and the elucidation of the genomic aspect of intratumor heterogeneity (ITH). Moreover, models of the evolution of the cancer genome have been proposed… read more here.
Keywords: selection pressure; evolution; intratumor heterogeneity; new therapeutic ... See more keywords