Site‐Selective Acylation of Vinylcyclopropanes under Visible‐Light Photocatalysis
Sign Up to like & getrecommendations! Published in 2024 at "Asian Journal of Organic Chemistry"
DOI: 10.1002/ajoc.202400325
Abstract: We herein disclose a protocol for linear‐selective ring‐opening acylation of a range of electron‐poor VCPs with α‐ketoacids by Ir‐photocatalyst. While electron‐poor VCPs could be sensitized with various radical species generated under different reaction conditions including… read more here.
Keywords: acylation; acylation vinylcyclopropanes; vinylcyclopropanes visible; visible light ... See more keywords
Selective Acylation of Proteins at Gly and Lys in His Tags
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DOI: 10.1002/cbic.202200359
Abstract: The chemical modification of proteins is of great importance in chemical biology, biotechnology, and for the production of modified biopharmaceuticals, as it enables introduction of fluorophores, biotin, half‐life extending moieties, and more. We have developed… read more here.
Keywords: selective acylation; gly lys; acylation; lys tags ... See more keywords
Carbene-catalyzed chirality-controlled site-selective acylation of saccharides
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DOI: 10.1038/s41467-024-55282-y
Abstract: Acylation stands as a fundamental process in both biological pathways and synthetic chemical reactions, with acylated saccharides and their derivatives holding diverse applications ranging from bioactive agents to synthetic building blocks. A longstanding objective in… read more here.
Keywords: acylation; site selective; site; acylation saccharides ... See more keywords
Synthesis of a fluorescent photoaffinity probe of OSW-1 by site-selective acylation of an inactive congener and biological evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08955k
Abstract: A novel fluorescent photoaffinity probe of OSW-1 was prepared in two steps from a naturally occurring inactive congener by a sequential site-selective acylation strategy using Me2SnCl2. It displayed highly potent anticancer activity and a similar… read more here.
Keywords: photoaffinity probe; site selective; selective acylation; probe osw ... See more keywords
Stannous chloride as a low toxicity and extremely cheap catalyst for regio-/site-selective acylation with unusually broad substrate scope
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DOI: 10.1039/d0gc02739a
Abstract: This work reports stannous chloride (SnCl2)-catalyzed regio-/site-selective acylation with unusually broad substrate scope. In addition to 1,2- and 1,3-diols and glycosides containing cis-vicinal diol, the substrate scope also includes glycosides without cis-vicinal diol. For such… read more here.
Keywords: site selective; regio site; selective acylation; substrate scope ... See more keywords
NHC/B(OH)3-mediated C3-selective acylation of unprotected monosaccharides: mechanistic insights and toward simpler/greener solutions
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DOI: 10.1039/d3gc05005j
Abstract: A simple and greener protocol for the regio-selective acylation of unprotected monosaccharides is achieved using boric acid as a promoter and N-heterocyclic carbene as an organic catalyst. read more here.
Keywords: greener; unprotected monosaccharides; nhc mediated; acylation unprotected ... See more keywords